ArticleBiophysical journal2006
The extracellular electrical resistivity in cell adhesion.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
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- Ultrastructural Analysis of Neuroimplant-Parenchyma Interfaces Uncover Remarkable Neuroregeneration Along-With Barriers That Limit the Implant Electrophysiological Functions.Frontiers in neuroscience · 2021Article
- Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality.Frontiers in neuroscience · 2020Article
- Minimizing activation of overlying axons with epiretinal stimulation: The role of fiber orientation and electrode configuration.PloS one · 2018Article
- Electrodiffusion phenomena in neuroscience: a neglected companion.Nature reviews. Neuroscience · 2017Review
- A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording.Scientific reports · 2016Article
- Current-Induced Transistor Sensorics with Electrogenic Cells.Biosensors · 2016Review
- Multi-electrode array technologies for neuroscience and cardiology.Nature nanotechnology · 2013Review
- Characterization of the cell-nanopillar interface by transmission electron microscopy.Nano letters · 2012Article
- Quantification of noise sources for amperometric measurement of quantal exocytosis using microelectrodes.The Analyst · 2012Article
- Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices.Journal of the Royal Society, Interface · 2009Article
- Transmission electron microscopy study of the cell-sensor interface.Journal of the Royal Society, Interface · 2008Article
- Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface.The European physical journal. E, Soft matter · 2007Article
- The mechanism of extracellular stimulation of nerve cells on an electrolyte-oxide-semiconductor capacitor.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of cells in a tissue depends on the nature of the extracellular matrix. The electrical properties of the narrow extracellular space are unknown. Here we consider cell adhesion mediated by extracellular matrix protein on a solid substrate as a model system. We culture human embryonic kidney (HEK293) cells on silica coated with fibronectin and determine the electrical resistivity in the cell-solid junction rhoJ=rJdJ by combining measurements of the sheet resistance rJ and of the distance dJ between membrane and substrate. The sheet resistance is obtained from phase fluorometry of the voltage-sensitive dye ANNINE-5 by alternating-current stimulation from the substrate. The distance is measured by fluorescence interference contrast microscopy. We change the resistivity of the bath in a range from 66 Omega cm to 750 Omega cm and find that the sheet resistance rJ is proportionally enhanced, but that the distance is invariant around dJ=75 nm. In all cases, the resulting resistivity rhoJ is indistinguishable from the resistivity of the bath. A similar result is obtained for rat neurons cultured on polylysine. On that basis, we propose a "bulk resistivity in cell adhesion" model for cell-solid junctions. The observations suggest that the electrical interaction between cells in a tissue is determined by an extracellular space with the electrical properties of bulk electrolyte.
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