ArticleThe Plant cell2006
Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
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Who cites it
229 citing papers in PubMed, 551 citations in OpenAlex.
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- Genomic analyses of weedy rice reveal historical connections between European and northwestern Chinese rice.Plant communications · 2026Article
- Rice Bran: A Comprehensive Review of Phytochemicals and Bioactive Components With Therapeutic Potential and Health Benefits.Nutrition reviews · 2026Review
- Genomic insights into the medieval cultivation history of influential high-yielding Asian rice.Scientific reports · 2026Article
- Integrative multi-omics analysis reveals the domestication mechanism of black rice.National science review · 2026Article
- Red pericarp trait, common to weedy rice, contributes to freezing tolerance of seeds and their ability to overwinter in soil.AoB PLANTS · 2026Article
- Genome-Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tissue-specific profiles of phenolic metabolites in rice deprived ofFrontiers in plant science · 2026Article
- Novel genome editing approaches to manipulate apical meristem activity for crop yield.Frontiers in plant science · 2026Review
- Spinach (Foods (Basel, Switzerland) · 2025Article
- Allele Mining of Seed-Related Genes Reveals Early movement, Selection and Adaptation of Asian Rice Landraces.Rice (New York, N.Y.) · 2025Article
- Pleiotropic effects of red and purple pericarp genes on seed coating patterns, flavonoids, dormancy, and germination in rice.G3 (Bethesda, Md.) · 2025Article
- Quantitative trait loci mapping of resistance to pre-harvest sprouting in the Norwegian spring wheat breeding line T7347.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Unlocking the potential of wild rice to bring missing nutrition to elite grains.Plant communications · 2025Review
- Advances and Future Prospects of Pigment Deposition in Pigmented Rice.Plants (Basel, Switzerland) · 2025Review
- Prime editing via precise sequence insertion restores function of the recessive rc allele in rice.Plant cell reports · 2025Article
- Natural variations inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Uncovering genetic determinants of antioxidant properties in Thai landrace rice through genome-wide association analysis.Scientific reports · 2025Article
- The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.).BMC plant biology · 2025Article
169 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rc is a domestication-related gene required for red pericarp in rice (Oryza sativa). The red grain color is ubiquitous among the wild ancestors of O. sativa, in which it is closely associated with seed shattering and dormancy. Rc encodes a basic helix-loop-helix (bHLH) protein that was fine-mapped to an 18.5-kb region on rice chromosome 7 using a cross between Oryza rufipogon (red pericarp) and O. sativa cv Jefferson (white pericarp). Sequencing of the alleles from both mapping parents as well as from two independent genetic stocks of Rc revealed that the dominant red allele differed from the recessive white allele by a 14-bp deletion within exon 6 that knocked out the bHLH domain of the protein. A premature stop codon was identified in the second mutant stock that had a light red pericarp. RT-PCR experiments confirmed that the Rc gene was expressed in both red- and white-grained rice but that a shortened transcript was present in white varieties. Phylogenetic analysis, supported by comparative mapping in rice and maize (Zea mays), showed that Rc, a positive regulator of proanthocyanidin, is orthologous with INTENSIFIER1, a negative regulator of anthocyanin production in maize, and is not in the same clade as rice bHLH anthocyanin regulators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.