ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 142 citations in OpenAlex.
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- Efficient strategies based on behavioral and electrophysiological methods for epilepsy-related gene screening in theFrontiers in molecular neuroscience · 2023Article
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- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
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- UNC13B variants associated with partial epilepsy with favourable outcome.Brain : a journal of neurology · 2021Article
- Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.Nature communications · 2021Article
- Knockout of PINK1 altered the neural connectivity of Drosophila dopamine PPM3 neurons at input and output sites.Invertebrate neuroscience : IN · 2020Article
- Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute theG3 (Bethesda, Md.) · 2019Article
11 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
Behavioral and genetic studies in Drosophila have contributed to our understanding of molecular mechanisms that underlie the complex processes of learning and memory. Use of this model organism for exploration of the cellular mechanisms of memory formation requires the ability to monitor synaptic activity in the underlying neural networks, a challenging task in the tiny adult fly. Here, we describe an isolated whole-brain preparation in which it is possible to obtain in situ whole-cell recordings from adult Kenyon cells, key members of a neural circuit essential for olfactory associative learning in Drosophila. The presence of sodium action potential (AP)-dependent synaptic potentials and synaptic currents in >50% of the Kenyon cells shows that these neurons are members of a spontaneously active neural circuit in the isolated brain. The majority of sodium AP-dependent synaptic transmission is blocked by curare and by alpha-bungarotoxin (alpha-BTX). This demonstrates that nicotinic acetylcholine receptors (nAChRs) are responsible for most of the spontaneous excitatory drive in this circuit in the absence of normal sensory input. Furthermore, analysis of sodium AP-independent synaptic currents provides the first direct demonstration that alpha-BTX-sensitive nAChRs mediate fast excitatory synaptic transmission in Kenyon cells in the adult Drosophila brain. This new preparation, in which whole-cell recordings and pharmacology can be combined with genetic approaches, will be critical in understanding the contribution of nAChR-mediated fast synaptic transmission to cellular plasticity in the neural circuits underlying olfactory associative learning.
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