Evidence map›Paper›PMID 16399670›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006

Branch-specific Ca2+ influx from Na+-dependent dendritic spikes in olfactory granule cells.

Tibor Zelles, Jamie D Boyd, Alexandre B Hardy, Kerry R Delaney

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Spatial Structure of Synchronized Inhibition in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  8. Two-Photon NaFrontiers in cellular neuroscience · 2017
    Article
  9. Article
  10. Article
  11. Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  12. Article
  13. Article
  14. Article
  15. NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  16. Active action potential propagation but not initiation in thalamic interneuron dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tibor ZellesDepartment of Biology, University of Victoria, Victoria, British Columbia V8W 3N5, Canada.
Jamie D Boyd
Alexandre B Hardy
Kerry R Delaney
University of Victoria · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two-photon laser scanning microscopy was used to correlate electrical events detected with whole-cell somatic recordings to Ca2+ transients in dendrites of olfactory bulb granule cells. A subset of spontaneous subthreshold depolarizing events recorded at the soma were shown to correspond to suprathreshold dendritic, Na-dependent action potentials [APs; dendritic spikes (D-spikes)]. These potentials were blocked by intracellular QX-314 (lidocaine N-ethyl bromide), hyperpolarizing current injection at the soma, and by partial inhibition of AMPA/kainate receptors with 0.75 microM DNQX. They were affected only slightly by 100 microM NiCl2. The majority of D-spikes recorded at the soma had a time to peak of <4 ms, comparable with somatic APs, a nonexponential decay, and amplitudes between 3 and 21 mV. Somatically recorded APs produced Ca2+ transients that were observed in spines and dendrites in all parts of the cell. Ca2+ transients from D-spikes were restricted to subsets of distal dendrites and their associated spines but were absent from the soma and dendrite within approximately 50-80 microm of the soma. Ca2+ transients in different branches could be correlated with different-sized D-spikes. D-spike and backpropagating AP-induced Ca2+ transients summed in dendrites, provided the interval between them was >5-6 ms. Generation of a D-spike in a particular dendrite <5-6 ms before a somatic AP blocked backpropagation of the somatic AP into that dendrite. The temporally specific interplay between D-spikes and backpropagating APs may play a role in regulating feedback and feedforward inhibition of groups of mitral cells synapsing on different granule cell dendrites.

Indexed as

Action PotentialsAnimalsBiological Transport, ActiveCalcium SignalingCations, DivalentDendritesIn Vitro TechniquesOlfactory BulbOlfactory Receptor NeuronsQuinoxalinesRana pipiensSodiumCations, DivalentFG 9041QuinoxalinesSodium

Identifiers

PMID16399670
PMCPMC6674300
OpenAlexW2001688314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.