ArticleCurrent genetics2006
Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026Review
- Protein Kinase A Negatively Regulates the Acetic Acid Stress Response inMicroorganisms · 2024Article
- Genetic effects on molecular network states explain complex traits.Molecular systems biology · 2023Article
- Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation.PloS one · 2019Article
- Nutrient and Stress Sensing in Pathogenic Yeasts.Frontiers in microbiology · 2019Review
- Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan.Aging cell · 2013Article
- Mapping yeast transcriptional networks.Genetics · 2013Review
- L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner.PloS one · 2012Article
- The role of the protein kinase A pathway in the response to alkaline pH stress in yeast.The Biochemical journal · 2011Article
- Mitochondria regulate autophagy by conserved signalling pathways.The EMBO journal · 2011Article
- Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation.The EMBO journal · 2011Article
- Transcriptional regulation in yeast during diauxic shift and stationary phase.Omics : a journal of integrative biology · 2010Review
- Article
- Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress.The Journal of biological chemistry · 2010Article
- Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and rapamycin treatment in Saccharomyces cerevisiae.The Journal of biological chemistry · 2010Article
- Regulon-specific control of transcription elongation across the yeast genome.PLoS genetics · 2009Article
- Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1.Molecular and cellular biology · 2009Article
- A molecular mechanism of chronological aging in yeast.Cell cycle (Georgetown, Tex.) · 2009Article
- Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.PLoS genetics · 2009Article
- Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The target of rapamycin (TOR) signaling pathway is an essential regulator of cell growth in eukaryotic cells. In Saccharomyces cerevisiae, TOR controls the expression of many genes involved in a wide array of distinct nutrient-responsive metabolic pathways. By exploring the TOR pathway under different growth conditions, we have identified novel TOR-regulated genes, including genes required for branched-chain amino acid biosynthesis as well as lysine biosynthesis (LYS genes). We show that TOR-dependent control of LYS gene expression occurs independently from previously identified LYS gene regulators and is instead coupled to cAMP-regulated protein kinase A (PKA). Additional genome-wide expression analyses reveal that TOR and PKA coregulate LYS gene expression in a pattern that is remarkably similar to genes within the ribosomal protein and "Ribi" regulon genes required for ribosome biogenesis. Moreover, this pattern of coregulation is distinct from other clusters of TOR/PKA coregulated genes, which includes genes involved in fermentation as well as aerobic respiration, suggesting that control of gene expression by TOR and PKA involves multiple modes of crosstalk. Our results underscore how multiple signaling pathways, general growth conditions, as well as the availability of specific nutrients contribute to the maintenance of appropriate patterns of gene activity in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.