ArticleThe Journal of physiology2006
Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5-HT.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- 2019 Ludwig Lecture: Rhythms in sympathetic nerve activity are a key to understanding neural control of the cardiovascular system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Review
- Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.Frontiers in physiology · 2020Review
- Central nervous system circuits that control body temperature.Neuroscience letters · 2019Review
- Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord.PLoS biology · 2018Article
- Autonomic dysreflexia: a cardiovascular disorder following spinal cord injury.Neural regeneration research · 2017Review
- What can we learn about neural control of the cardiovascular system by studying rhythms in sympathetic nerve activity?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Review
- Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Computational solution of spike overlapping using data-based subtraction algorithms to resolve synchronous sympathetic nerve discharge.Frontiers in computational neuroscience · 2013Article
- Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice.Neuroscience · 2010Article
- Multiple thermoregulatory effectors with independent central controls.European journal of applied physiology · 2010Review
- Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: effect of olfactory ensheathing glia.The Journal of comparative neurology · 2009Article
- Central pathway for spontaneous and prostaglandin E2-evoked cutaneous vasoconstriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat.Autonomic neuroscience : basic & clinical · 2008Article
- Multi-tasking in the spinal cord--do 'sympathetic' interneurones work harder than we give them credit for?The Journal of physiology · 2007Review
- Serotonin potentiates sympathetic responses evoked by spinal NMDA.The Journal of physiology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When applied in vitro to various CNS structures 5-HT and/or NMDA have been observed to generate rhythmic nervous activity. In contrast, reports of similar in vivo actions are relatively rare. Here we describe a physiological sympathetic motor rhythm regulating the thermoregulatory circulation of the rat tail (T-rhythm; 0.40-1.20 Hz) that can be elicited following intrathecal (i.t.) application of 5-HT to an in situ'isolated' spinal cord preparation (anaesthetized rats spinalized at T10-T11 and cauda equina cut). i.t. injections were delivered to L1 as sympathetic neuronal activity to the tail (SNAT) arises from preganglionic neurones at T11-L2. SNAT was abolished after spinal transection (n = 18) and it did not return spontaneously. The administration of 5-HT (250 nmol) generated rhythmic sympathetic discharges (n = 6). The mean frequency of the T-like rhythm during the highest level of activity was 0.88 +/- 0.04 Hz which was not significantly different from the T-rhythm frequency observed in intact animals (0.77 +/- 0.02 Hz; P > 0.05 n = 16). In contrast, NMDA (1 micromol) generated an irregular tonic activity, but it failed to generate a T-like rhythm (n = 9), even though the mean levels of activity were not significantly different to those produced by 5-HT. However, 5-HT (250 nmol) applied after NMDA generated a T-like rhythm (0.95 +/- 0.11 Hz, n = 6). Our observations support the idea that 5-HT released from rostral ventromedial medullary neurones, known to innervate sympathetic preganglionic neurones, can induce sympathetic rhythmic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.