ArticleThe EMBO journal2006
A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 78 citations in OpenAlex.
- Shared Disease Mechanisms in Neurodevelopmental Disorders: A Cellular and Molecular Biology Perspective.Brain sciences · 2025Review
- Fine-tuning cell organelle dynamics during mitosis by small GTPases.Frontiers of medicine · 2022Review
- Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.BMJ open diabetes research & care · 2021Article
- RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.Development (Cambridge, England) · 2020Article
- Rabgap1 promotes recycling of active β1 integrins to support effective cell migration.Journal of cell science · 2020Article
- Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity inJournal of cell science · 2018Article
- The MLL recombinome of acute leukemias in 2017.Leukemia · 2018Article
- Review
- Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation.Scientific reports · 2016Article
- Rab6a is a novel regulator of meiotic apparatus and maturational progression in mouse oocytes.Scientific reports · 2016Article
- Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells.Scientific reports · 2016Article
- GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance.F1000Research · 2016Article
- Small RAB GTPases Regulate Multiple Steps of Mitosis.Frontiers in cell and developmental biology · 2016Review
- Review
- Mechanisms and Regulation of the Mitotic Inheritance of the Golgi Complex.Frontiers in cell and developmental biology · 2015Review
- Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.Oncoscience · 2014Article
- A new role for Rab GTPases during early mitotic stages.Small GTPases · 2014Article
- Protein adaptation: mitotic functions for membrane trafficking proteins.Nature reviews. Molecular cell biology · 2013Review
- Small GTPases as regulators of cell division.Communicative & integrative biology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The two isoforms of the Rab6 GTPase, Rab6A and Rab6A', regulate a retrograde transport route connecting early endosomes and the endoplasmic reticulum via the Golgi complex in interphasic cells. Here we report that when Rab6A' function is altered cells are unable to progress normally through mitosis. Such cells are blocked in metaphase, despite displaying a normal Golgi fragmentation and with the Mad2-spindle checkpoint activated. Furthermore, the Rab6 effector p150(Glued), a subunit of the dynein/dynactin complex, remains associated with some kinetochores. A similar phenotype was observed when GAPCenA, a GTPase-activating protein of Rab6, was depleted from cells. Our results suggest that Rab6A' likely regulates the dynamics of the dynein/dynactin complex at the kinetochores and consequently the inactivation of the Mad2-spindle checkpoint. Rab6A', through its interaction with p150(Glued) and GAPCenA, may thus participate in a pathway involved in the metaphase/anaphase transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.