ArticleInfection and immunity1992
Antibody responses to the chlamydial heat shock proteins hsp60 and hsp70 are H-2 linked.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- The SWIB domain-containing DNA topoisomerase I ofJournal of bacteriology · 2025Article
- Identification of MHCII variants associated with chlamydial disease in the koala (Phascolarctos cinereus).PeerJ · 2014Article
- Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.American journal of obstetrics and gynecology · 2010Article
- Article
- Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome.Infection and immunity · 2008Article
- The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis.Infection and immunity · 2006Article
- Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins.Infection and immunity · 2006Article
- Association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in Chlamydia-infected koalas.Clinical and diagnostic laboratory immunology · 2005Article
- Human antibody responses to a Chlamydia-secreted protease factor.Infection and immunity · 2004Article
- Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors.Infection and immunity · 2004Article
- Chlamydial serology: comparative diagnostic value of immunoblotting, microimmunofluorescence test, and immunoassays using different recombinant proteins as antigens.Journal of clinical microbiology · 2001Article
- Serological investigation of Chlamydia trachomatis heat shock protein 10.Infection and immunity · 1999Article
- Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing variable domain 4 of the major outer membrane protein of Chlamydia trachomatis.Clinical and diagnostic laboratory immunology · 1999Article
- Pathogenesis of Chlamydia induced pelvic inflammatory disease.Sexually transmitted infections · 1999Review
- Heat shock protein expression and immunity in chlamydial infections.Infectious diseases in obstetrics and gynecology · 1999Review
- Evidence of genetic susceptibility to Chlamydia trachomatis-induced pelvic inflammatory disease in the pig-tailed macaque.Infection and immunity · 1997Article
- Reactivation of chlamydial genital tract infection in mice.Infection and immunity · 1997Article
- Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge.Infection and immunity · 1996Article
- Immune consequences of Chlamydia infections in pregnancy and in vitro fertilization outcome.Infectious diseases in obstetrics and gynecology · 1996Article
- Immune response to Chlamydia trachomatis heat-shock protein in infertile female patients and influence of Chlamydia pneumoniae antibodies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of both H-2 and non-H-2 genes on antibody responses to two Chlamydia trachomatis heat shock proteins (hsp60 and hsp70) were investigated. These chlamydial proteins are homologs of Escherichia coli GroEL (hsp60) and DnaK (hsp70) and are highly sequence conserved between bacterial and mammalian sources. Antibody responses among 17 different strains of mice immunized with C. trachomatis serovar B and serovar C elementary bodies were evaluated by immunoblot, radioimmunoprecipitation and enzyme-linked immunosorbent assay. Antibody responses to the two proteins displayed host genetic restriction. Of six distinctive H-2 haplotypes, only H-2d generated high antibody responses to hsp70. Five of the six H-2 haplotypes, i.e., H-2a, H-2d, H-2k, H-2q, and H-2s, produced high antibody responses to hsp60. Only the H-2b-bearing strain had low antibody responses to hsp60. By using congenic and H-2 recombinant strains, the genes responsible for regulating antibody responses to hsp70 and hsp60 were mapped to the K-IA region of the H-2 locus. In F1 hybrid crosses between high and low responders, high responses to hsp60 and hsp70 were dominant traits. Other genes outside the H-2 locus also influenced antibody responses to hsp60 and hsp70, since inbred strains of identical H-2 but different background genes displayed variable antibody responses to the proteins. The genetic control of murine immune responses to C. trachomatis hsp60, a putative chlamydial immunopathologic antigen, suggests that a similar genetic mechanism may also exist in humans, and this observation may help to explain the observed variability in the spectrum of chlamydial diseases seen in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.