ArticleJournal of immunology (Baltimore, Md. : 1950)2006
Early preplasma cells define a tolerance checkpoint for autoreactive B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Article
- Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes-Prone Mice.ImmunoHorizons · 2023Article
- Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes.Diabetologia · 2023Article
- Low-Level Expression of CD138 Marks Naturally Arising Anergic B Cells.Immune network · 2022Article
- Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice.Diabetologia · 2019Article
- Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.Immunological reviews · 2019Review
- Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Article
- Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.Cellular & molecular immunology · 2017Article
- Death receptor 6 contributes to autoimmunity in lupus-prone mice.Nature communications · 2017Article
- IgD attenuates the IgM-induced anergy response in transitional and mature B cells.Nature communications · 2016Article
- Maintenance of autoantibody production in pristane-induced murine lupus.Arthritis research & therapy · 2015Article
- Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Journal of autoimmunity · 2015Article
- Article
- Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.Arthritis and rheumatism · 2012Article
- Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
Ab-secreting plasma cells (PCs) are the effectors of humoral immunity. In this study, we describe regulation of autoreactive B cells specific for the ribonucleoprotein Smith (Sm) at an early pre-PC stage. These cells are defined by the expression of the PC marker CD138 and normal levels of CD19 and B220. They are present at a high frequency in normal mouse spleen and bone marrow, are Ag dependent, and are located predominantly along the T cell-B cell border and near bridging channels. Anti-Sm pre-PCs also occur at a high frequency in nonautoimmune mice and show additional phenotypic characteristics of PC differentiation. However, while some of these pre-PCs are Ab-secreting cells, those specific for Sm are not, indicating regulation. Consistent with this, anti-Sm pre-PCs have a higher turnover rate and higher frequency of cell death than those that do not bind Sm. Regulation of anti-Sm pre-PCs occurs upstream of the transcriptional repressor, B lymphocyte-induced maturation protein-1, expression. Regulation at this stage is overcome in autoimmune MRL/lpr mice and is accompanied by an altered B lymphocyte stimulator receptor profile. These data reveal a new B cell tolerance checkpoint that is overcome in autoimmunity.
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