ArticleEnvironmental health perspectives2006
The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers, 7 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
222 citing papers in PubMed, 7 syntheses or guidelines pooled it, 626 citations in OpenAlex.
- Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Frontiers in endocrinology · 2026Pooled it
- The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus.International journal of environmental research and public health · 2022Pooled it
- Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.Environmental health : a global access science source · 2022Pooled it
- Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis.BMC endocrine disorders · 2018Pooled it
- The association between bisphenol A exposure and type-2 diabetes: a world systematic review.Environmental science and pollution research international · 2016Pooled it
- Bisphenol A and the risk of cardiometabolic disorders: a systematic review with meta-analysis of the epidemiological evidence.Environmental health : a global access science source · 2015Pooled it
- Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence.Current diabetes reports · 2013Pooled it
- Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial.The Journal of clinical endocrinology and metabolism · 2026Trial
- Emerging evidence for skeletal muscle as a target of BPA exposure.BMC endocrine disorders · 2026Review
- Endocrine disruptors are contributing to type 2 diabetes mellitus.Hormones (Athens, Greece) · 2026Review
- Exposure to phthalate and phenol mixtures and obesity in children and adolescents: the dominant role of bisphenol A.Lipids in health and disease · 2026Article
- Review
- Effects of Endocrine Disrupting Chemicals on Fetal Weight: Exposure Monitoring Among Mothers with Gestational Diabetes Mellitus and Their Fetuses.International journal of molecular sciences · 2025Article
- Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- LOW-RANK LONGITUDINAL FACTOR REGRESSION WITH APPLICATION TO CHEMICAL MIXTURES.The annals of applied statistics · 2025Article
- Microplastic and nanoplastic exposure and risk of diabetes mellitus.World journal of clinical cases · 2025Article
- The Silent Threat of BPA: Its Pervasive Presence and Impact on Reproductive Health.Environmental health insights · 2025Review
- Deciphering the role of classical oestrogen receptor in insulin resistance and type 2 diabetes mellitus: From molecular mechanism to clinical evidence.BioImpacts : BI · 2025Review
- Metabolic disrupting chemicals in the intestine: the need for biologically relevant models: Zebrafish: what can we learn from this small environment-sensitive fish?FEBS open bio · 2024Review
- Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption.Materials today. Bio · 2024Review
162 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of the pancreatic beta-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17beta-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 microg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E2 and BPA induce an increase in pancreatic beta-cell insulin content in an estrogen-receptor-dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 microg/kg/day. After 4 days of treatment with either E2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.