ArticleEnvironmental health perspectives2006
Exposure, postexposure, and density-mediated effects of atrazine on amphibians: breaking down net effects into their parts.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- A qualitative meta-analysis reveals consistent effects of atrazine on freshwater fish and amphibians.Environmental health perspectives · 2010Pooled it
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- A pesticide paradox: fungicides indirectly increase fungal infections.Ecological applications : a publication of the Ecological Society of America · 2017Article
- The pros and cons of ecological risk assessment based on data from different levels of biological organization.Critical reviews in toxicology · 2016Review
- Transforming ecosystems: When, where, and how to restore contaminated sites.Integrated environmental assessment and management · 2016Article
- Combined Effects of Pesticides and Trematode Infections on Hourglass Tree Frog Polypedates cruciger.EcoHealth · 2016Article
- Success stories and emerging themes in conservation physiology.Conservation physiology · 2016Article
- Trophic dynamics in an aquatic community: interactions among primary producers, grazers, and a pathogenic fungus.Oecologia · 2015Article
- A synthesis of the effects of pesticides on microbial persistence in aquatic ecosystems.Critical reviews in toxicology · 2015Review
- Sublethal effects of atrazine and glyphosate on life history traits of Aedes aegypti and Aedes albopictus (Diptera: Culicidae).Parasitology research · 2014Article
- Article
- Early-life exposure to a herbicide has enduring effects on pathogen-induced mortality.Proceedings. Biological sciences · 2013Article
- Article
- The fungicide chlorothalonil is nonlinearly associated with corticosterone levels, immunity, and mortality in amphibians.Environmental health perspectives · 2011Article
- Juvenile green frog (Rana clamitans) predatory ability not affected by exposure to carbaryl at different times during larval development.Environmental toxicology and chemistry · 2011Article
- Carry-over effects of the larval environment on post-metamorphic performance in two hylid frogs.Oecologia · 2010Article
- Spatial variation in abiotic and biotic factors in a floodplain determine anuran body size and growth rate at metamorphosis.Oecologia · 2010Article
- The cause of global amphibian declines: a developmental endocrinologist's perspective.The Journal of experimental biology · 2010Article
- Parasites, info-disruption, and the ecology of fear.Oecologia · 2009Article
- Combined effects of atrazine and chlorpyrifos on susceptibility of the tiger salamander to Ambystoma tigrinum virus.EcoHealth · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most toxicology studies focus on effects of contaminants during exposure. This is disconcerting because subsequent survival may be affected. For instance, contaminant-induced mortality can be later ameliorated by reduced competition among the survivors, a concept we refer to as "density-mediated compensation." Alternatively, it can be exacerbated by toxicant effects that persist or appear after exposure, a phenomenon we term "carryover effects." We developed a laboratory framework for testing the contribution of exposure, density-mediated, and carryover effects to net survival, by exposing embryos and larvae of the streamside salamander (Ambystoma barbouri) to atrazine (0, 4, 40, 400 ppb; 3 ppb is the U.S. drinking water maximum) and quantifying survival during and 14 months after exposure. Atrazine is the most commonly used herbicide in the United States and a documented endocrine disruptor. We show that atrazine-induced mortality during exposure was ameliorated by density-dependent survival after exposure, but complete density-mediated compensation was precluded by significant carryover effects of atrazine. Consequently, salamanders exposed to >or=4 ppb of atrazine had significantly lower survival than did control animals 14 months postexposure. The greatest change in survival occurred at low exposure concentrations. These nonlinear, long-term, postexposure effects of atrazine have similarities to effects of early development exposure to other endocrine disruptors. Together with evidence of low levels of atrazine impairing amphibian gonadal development, the results here raise concerns about the role of atrazine in amphibian declines and highlight the importance of considering persistent, postexposure effects when evaluating the impact of xenobiotics on environmental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.