ReviewEnvironmental health perspectives2006
Recent applications of DNA microarray technology to toxicology and ecotoxicology.
Review in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.
- Sensitive and robust gene expression changes in fish exposed to estrogen--a microarray approach.BMC genomics · 2007Pooled it
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- Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications.BioData mining · 2025Article
- Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue.Frontiers in toxicology · 2022Article
- Biomarker Responses, Gene Expression Alterations, and Histological Changes in Zebrafish (Frontiers in physiology · 2022Article
- Character-based identification system of scombrids from Indian waters for authentication and conservation purposes.Mitochondrial DNA. Part B, Resources · 2020Article
- TinderMIX: Time-dose integrated modelling of toxicogenomics data.GigaScience · 2020Article
- Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects.Nanomaterials (Basel, Switzerland) · 2020Review
- Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data.Molecular omics · 2018Review
- Ensemble of rankers for efficient gene signature extraction in smoke exposure classification.BMC bioinformatics · 2018Article
- Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos.Environmental science and pollution research international · 2018Article
- Global gene expression profiling using heterologous DNA microarrays to analyze alterations in the transcriptome of Mus spretus mice living in a heavily polluted environment.Environmental science and pollution research international · 2016Article
- Effect of silver nanoparticles on the standard soil arthropodEnvironmental sciences Europe · 2016Article
- Fold-change threshold screening: a robust algorithm to unmask hidden gene expression patterns in noisy aggregated transcriptome data.Environmental science and pollution research international · 2015Article
- Hepatic Transcriptome Responses in Mice (Mus musculus) Exposed to the Nafion Membrane and Its Combustion Products.PloS one · 2015Article
- Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.BMC genomics · 2014Article
- Discovery and validation of gene classifiers for endocrine-disrupting chemicals in zebrafish (danio rerio).BMC genomics · 2012Article
- Nonvolatile copolymer compositions for fabricating gel element microarrays.Analytical biochemistry · 2012Article
- Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression is a unique way of characterizing how cells and organisms adapt to changes in the external environment. The measurements of gene expression levels upon exposure to a chemical can be used both to provide information about the mechanism of action of the toxicant and to form a sort of "genetic signature" for the identification of toxic products. The development of high-quality, commercially available gene arrays has allowed this technology to become a standard tool in molecular toxicology. Several national and international initiatives have provided the proof-of-principle tests for the application of gene expression for the study of the toxicity of new and existing chemical compounds. In the last few years the field has progressed from evaluating the potential of the technology to illustrating the practical use of gene expression profiling in toxicology. The application of gene expression profiling to ecotoxicology is at an earlier stage, mainly because of the the many variables involved in analyzing the status of natural populations. Nevertheless, significant studies have been carried out on the response to environmental stressors both in model and in nonmodel organisms. It can be easily predicted that the development of stressor-specific signatures in gene expression profiling in ecotoxicology will have a major impact on the ecotoxicology field in the near future. International collaborations could play an important role in accelerating the application of genomic approaches in ecotoxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.