Trial reportEuropean journal of clinical nutrition2006
Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults.
Trial report in European journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.European journal of clinical nutrition · 2019Pooled it
- Vitamin D supplementation for prevention of mortality in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Sun Exposure and Behavioral Activation for Hypovitaminosis D and Depression: A Controlled Pilot Study.Community mental health journal · 2018Trial
- Effect of calcium phosphate and vitamin D₃ supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron.Nutrition journal · 2014Trial
- Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?European journal of nutrition · 2010Trial
- Vitamin D Status Assessment: Lack of Correlation between Serum and Hair 25-Hydroxycholecalciferol Levels in Healthy Young Adults.Diagnostics (Basel, Switzerland) · 2022Article
- Effect of Vitamin D Levels on Bone Remodeling in Healthy Women.International journal of endocrinology and metabolism · 2020Article
- Overfed but undernourished: recognizing nutritional inadequacies/deficiencies in patients with overweight or obesity.International journal of obesity (2005) · 2019Review
- Improving Vitamin D Status and Related Health in Young Women: The Safe-D study - Part B.JMIR research protocols · 2016Article
- Effect of vitamin DBone reports · 2015Article
- Per oral substitution with 300000 IU vitamin D (Cholecalciferol) reduces bone turnover markers in HIV-infected patients.BMC infectious diseases · 2013Article
- Article
- Changes in the vitamin D endocrine system and bone turnover after oral vitamin D3 supplementation in healthy adults: results of a randomised trial.BMC endocrine disorders · 2012Article
- Vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates.Dermato-endocrinology · 2011Article
- Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology.Nutrition journal · 2010Article
- Effect of Vitamin D Supplementation on Bone Turnover Markers in Children and Adolescents from North India.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover.
designDouble-blinded randomised controlled intervention study.
settingUniversity of Ulster, Coleraine, Northern Ireland. SUBJECTS: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention.
interventionsSubjects were randomly assigned, to receive either 15 microg (600 IU) vitamin D(3) and 1,500 mg calcium/day (vitamin D group), or 1,500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.
resultsAt baseline, vitamin D status was low in both the vitamin D group (47.9 (s.d. 16.0)) and the control group (55.5 (s.d. 18.6) nmol/l 25(OH)D). Post intervention vitamin D status was significantly higher in the vitamin D-treated group (86.5 (s.d. 24.5)) compared to the control group (48.3 (s.d. 16.8) nmol/l) (P<0.0001). There was no significant effect of supplementation on bone turnover markers or PTH concentrations.
conclusionsThis study suggests that young adults in Northern Ireland do not consume an adequate daily dietary intake of vitamin D to maintain plasma vitamin D concentrations in the wintertime. A daily supplement of 15 microg vitamin D(3) significantly increased vitamin D status in these individuals to levels of sufficiency. Achievement of an optimum vitamin D status among young adults may have future positive health implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.