Evidence map›Paper›PMID 16391447›Full record

Trial reportIndian journal of pediatrics2005

Efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea.

Vikrant Khanna, Seema Alam, Ashraf Malik, Abida Malik

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Indian journal of pediatrics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 7 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 7 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2010
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Particulate Cell Wall Materials ofVeterinary sciences · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vikrant KhannaDepartment of Pediatrics, JN Medical College, Aligarh Muslim University, Aligarh, India.
Seema Alam
Ashraf Malik
Abida Malik
Aligarh Muslim University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea.

methodsAll children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 the placebo.

resultsORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance.

conclusionThere is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.

Indexed as

Lactobacillus acidophilusAcute DiseaseChildChild, PreschoolCombined Modality TherapyDiarrheaDouble-Blind MethodFluid TherapyHumansInfantProbiotics

Identifiers

PMID16391447
OpenAlexW2011416971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.