ReviewNeuromolecular medicine2005
Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder.
Review in Neuromolecular medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Molecular psychiatry · 2007Pooled it
- Trial
- Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence.Current topics in medicinal chemistry · 2020Article
- Cognitive Performance in Euthymic Patients with Bipolar Disorder vs Healthy Controls: A Neuropsychological Investigation.Clinical practice and epidemiology in mental health : CP & EMH · 2017Article
- Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.Neuroscience bulletin · 2014Article
- Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis.Journal of psychiatry & neuroscience : JPN · 2014Article
- Everyday functional ability across different phases of bipolar disorder.Psychiatry research · 2013Article
- DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder.PloS one · 2012Article
- Epigenetics and biomarkers in the staging of neuropsychiatric disorders.Neurotoxicity research · 2010Review
- Cognitive functioning in patients with bipolar disorder: association with depressive symptoms and alcohol use.PloS one · 2010Article
- Intermediate: cognitive phenotypes in bipolar disorder.Journal of affective disorders · 2010Article
- Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task.Human brain mapping · 2009Article
- Neurocognition in bipolar disorder and juvenile bipolar disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2009Article
- Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder.Journal of psychiatric research · 2009Article
- Neurocognitive impairment in unaffected siblings of youth with bipolar disorder.Psychological medicine · 2009Article
- Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Neurocognitive function in an extended Afrikaner-ancestry family with affective illness.Journal of psychiatry & neuroscience : JPN · 2007Article
- The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression.Neural plasticity · 2007Review
- A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.Neuromolecular medicine · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic basis of bipolar affective disorder remains opaque despite years of intensive investigation. One of the most serious difficulties for genetic research is the enormous phenotypic heterogeneity of psychiatric illnesses. As a response to this problem, geneticists have searched for alternative strategies to identify those individuals at genetic risk for developing the disorder. One approach is to use endophenotypes or intermediate traits. Gottesman and Gould (2003), in their discussion of endophenotypes, suggest five criteria that should be characteristic of a trait in order for it to qualify as an endophenotype. These five criteria are used in order to assess the viability of using measures of neuropsychological dysfunction as endophenotypes for genetic studies of bipolar disorder. A review of the literature suggests that executive dysfunction is characteristic of people with bipolar disorder in both the acute and chronic stages of the illness, that neurocognitive function is influenced by genetic factors and that neuropsychological deficits have been reported in the nonaffected relatives of bipolar probands. Nevertheless, it is unclear whether neuropsychological dysfunction co-segregates with affectively ill individuals. We conclude that the use of neurocognitive markers of bipolar illness suffers from a number of serious drawbacks but given the absence of more appropriate endophenotypes, the neuropsychological profiling of probands and their relatives may nevertheless prove to be a worthwhile exercise.
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