ArticleApplied and environmental microbiology2006
Putative ABC transporter responsible for acetic acid resistance in Acetobacter aceti.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 107 citations in OpenAlex.
- Quantitative Metaproteomic Characterization of Acetic Acid Bacteria Reveals Functional Dynamics During Verdejo Wine Acetification.Proteomes · 2026Article
- Evidence for ethanol-dependent acetic acid resistance inApplied and environmental microbiology · 2025Article
- Complete genome analysis of the cellulose producing strain Komagataeibacter sucrofermentans SMEG01.Scientific reports · 2025Article
- Bioleaching for critical metal recovery from bauxite residue- unlocking waste valorization.Frontiers in bioengineering and biotechnology · 2025Review
- Regulatory mechanisms of acetic acid, ethanol and high temperature tolerances of acetic acid bacteria during vinegar production.Microbial cell factories · 2024Review
- Implementation of a Novel Method for Processing Proteins from Acetic Acid Bacteria via Liquid Chromatography Coupled with Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Advanced Electroanalysis for Electrosynthesis.ACS organic & inorganic Au · 2024Review
- Investigation of Acid Tolerance Mechanism ofFoods (Basel, Switzerland) · 2023Article
- Improving the Acetic Acid Fermentation ofFrontiers in bioengineering and biotechnology · 2022Article
- RNA-Seq transcriptomic analysis reveals gene expression profiles of acetic acid bacteria under high-acidity submerged industrial fermentation process.Frontiers in microbiology · 2022Article
- Leucine-Responsive Regulatory Protein in Acetic Acid Bacteria Is Stable and Functions at a Wide Range of Intracellular pH Levels.Journal of bacteriology · 2021Article
- Fine-tuning ethanol oxidation pathway enzymes and cofactor PQQ coordinates the conflict between fitness and acetic acid production by Acetobacter pasteurianus.Microbial biotechnology · 2021Article
- Review
- Toxin-antitoxin HicAB regulates the formation of persister cells responsible for the acid stress resistance in Acetobacter pasteurianus.Applied microbiology and biotechnology · 2021Article
- Investigation of lipid profile in Acetobacter pasteurianus Ab3 against acetic acid stress during vinegar production.Extremophiles : life under extreme conditions · 2020Article
- Genome-Scale Metabolic Reconstruction ofFrontiers in microbiology · 2019Article
- Effect of Sequential Acclimation to Various Carbon Sources on the Proteome ofFrontiers in microbiology · 2019Article
- Bacterial Acid Resistance Toward Organic Weak Acid Revealed by RNA-Seq Transcriptomic Analysis inFrontiers in microbiology · 2019Article
- Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01.Scientific reports · 2017Article
- Genome Sequence ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-dimensional gel electrophoretic analysis of the membrane fraction of Acetobacter aceti revealed the presence of several proteins that were produced in response to acetic acid. A 60-kDa protein, named AatA, which was mostly induced by acetic acid, was prepared; aatA was cloned on the basis of its NH2-terminal amino acid sequence. AatA, consisting of 591 amino acids and containing ATP-binding cassette (ABC) sequences and ABC signature sequences, belonged to the ABC transporter superfamily. The aatA mutation with an insertion of the neomycin resistance gene within the aatA coding region showed reduced resistance to acetic acid, formic acid, propionic acid, and lactic acid, whereas the aatA mutation exerted no effects on resistance to various drugs, growth at low pH (adjusted with HCl), assimilation of acetic acid, or resistance to citric acid. Introduction of plasmid pABC101 containing aatA under the control of the Escherichia coli lac promoter into the aatA mutant restored the defect in acetic acid resistance. In addition, pABC101 conferred acetic acid resistance on E. coli. These findings showed that AatA was a putative ABC transporter conferring acetic acid resistance on the host cell. Southern blot analysis and subsequent nucleotide sequencing predicted the presence of aatA orthologues in a variety of acetic acid bacteria belonging to the genera Acetobacter and Gluconacetobacter. The fermentation with A. aceti containing aatA on a multicopy plasmid resulted in an increase in the final yield of acetic acid.
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