ArticleBritish journal of clinical pharmacology2006
Thiazide diuretic prescription and electrolyte abnormalities in primary care.
Article in British journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Association between antihypertensive treatment and adverse events: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2021Pooled it
- A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?British journal of clinical pharmacology · 2015Pooled it
- Biochemical monitoring of patients treated with antihypertensive therapy for adverse drug reactions: a systematic review.Drug safety · 2011Pooled it
- Costs of eprosartan versus diuretics for treatment of hypertension in a geriatric population: an observational, open-label, multicentre study.Drugs & aging · 2009Trial
- Comparative efficacy and safety of chlorthalidoneWorld journal of cardiology · 2026Article
- Early-Onset Thiazide-Induced Hyponatremia Leading to Seizure in a Middle-Aged Woman Using Aldactazide.Case reports in nephrology · 2026Article
- Prevalence and Determinants of Hyponatremia in Hospitalized Patients at a Tertiary Care Center in Mumbai.Cureus · 2025Article
- Drug-Induced Hyponatremia: Insights into Pharmacological Mechanisms and Clinical Practice Management.Journal of clinical medicine · 2025Review
- The Effect of Thiazide Diuretics on Urinary Prostaglandin E2 Excretion and Serum Sodium in the General Population.The Journal of clinical endocrinology and metabolism · 2024Article
- Thiazide-Induced Hyponatremia Presenting as a Fall in an Older Adult.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Article
- Prevalence and Factors Associated with Potassium Abnormalities Among Outpatients with Heart Failure Taking Diuretics in a Tertiary Referral Hospital in Tanzania.The East African health research journal · 2024Article
- Thiazide-associated hyponatremia increases the risk of major adverse cardiovascular events among elderly Taiwanese patients.BMC geriatrics · 2023Article
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Article
- Hormones and Aging: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Incidence of severe hypokalaemia in patients taking indapamide.Internal and emergency medicine · 2023Article
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
- Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma.Medicina (Kaunas, Lithuania) · 2021Article
- Prevalence of hypokalemia in older persons: results from the PolSenior national survey.European geriatric medicine · 2021Article
- Safety of low-volume PEG-asc bowel cleansing preparation for colonoscopy: identifying patients at risk for hypokalemia in a prospective cohort study.Endoscopy international open · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThiazide diuretics have a number of well-documented metabolic adverse effects. The aim of this study was to estimate the frequency of hyponatraemia and hypokalaemia amongst patients taking a thiazide diuretic in primary care.
methodsA computerized search of the electronic prescribing and laboratory records of six UK general practices was performed. Of the 32 218 adult patients identified, 3773 had received at least one prescription for a thiazide between the years 1990 and 2002.
resultsDetailed prescribing data were available for 2942 patients of whom 951 (32.3%) had a recorded check of their electrolytes. One hundred and ninety-six (20.6%) had a sodium and/or potassium concentration below the normal range. The sodium distribution had a negative skew (-1.8) and in 130 (13.7%) patients was within the hyponatraemic range. Hypokalaemia was less common, occurring in 79 (8.5%) patients. Hyponatraemia was significantly associated with increased age; the odds ratio for developing hyponatraemia in patients over 70 years was 3.87 compared with those of < or = 70 years. Hypokalaemia was significantly associated with increased thiazide dose.
conclusionsPrescription of a thiazide diuretic in primary care is associated with a high frequency of hyponatraemia and hypokalaemia. Thiazides should be prescribed at low dose and the risk of hyponatraemia, especially in the elderly, should be considered and monitored for when prescribing these agents.
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