ReviewBrain pathology (Zurich, Switzerland)2005
The role of the extracellular matrix in angiogenesis in malignant glioma tumors.
Review in Brain pathology (Zurich, Switzerland), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- The Extracellular Matrix, the Silent 'Architect' of Glioma.Biomedicines · 2026Review
- Article
- Review
- Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis.Acta neuropathologica communications · 2023Article
- Single-Cell Transcriptome of Wet AMD Patient-Derived Endothelial Cells in Angiogenic Sprouting.International journal of molecular sciences · 2022Article
- The Role of Brain Vasculature in Glioblastoma.Molecular neurobiology · 2019Review
- The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma.Molecular cancer research : MCR · 2016Article
- Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis.Journal of experimental & clinical cancer research : CR · 2015Article
- TGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cells.Neuro-oncology · 2013Article
- Article
- Article
- Mechanisms of glioma-associated neovascularization.The American journal of pathology · 2012Review
- Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma.Cancer research · 2012Article
- Endoscopy-verified occult subependymal dissemination of glioblastoma and brain metastasis undetected by MRI: prognostic significance.OncoTargets and therapy · 2012Article
- New agents targeting angiogenesis in glioblastoma.Chemotherapy research and practice · 2011Article
- Vascular gene expression patterns are conserved in primary and metastatic brain tumors.Journal of neuro-oncology · 2010Article
- Galectins and gliomas.Brain pathology (Zurich, Switzerland) · 2010Review
- Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.Journal of oncology · 2010Article
- Biology of angiogenesis and invasion in glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2009Review
- Angiogenesis as a therapeutic target in malignant gliomas.The oncologist · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Angiogenesis is a promising target for the development of effective strategies for the treatment of malignant brain tumors in that it has the potential to starve large tumors and prevent the regrowth of residual margins. Two critical steps in angiogenesis, the proliferation of activated endothelial cells and their migration into the perivascular space (sprouting), require adherence of the endothelial cells to the extracellular matrix (ECM). Thus, the availability of the appropriate ligands within the ECM contributes to the regulation of angiogenesis. In addition, several components of the ECM can act through other mechanisms to further promote angiogenesis or inhibit it. Current evidence suggests that the regulation of angiogenesis is a dynamic process in which the endothelial cells can promote angiogenesis by secreting proteases that remodel the ECM, tumor cells can further promote angiogenesis by secreting ECM components and actively remodeling their environment, and stromal cells may respond to angiogenesis associated with tumors and inflammatory reactions by secreting inhibitory molecules. Here, we provide a critical review of the protein and proteoglycan components of the ECM that have been implicated in angiogenesis with an emphasis on their role in promoting or inhibiting angiogenesis in brain tumors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.