ArticleBrain pathology (Zurich, Switzerland)2005
Injections of blood, thrombin, and plasminogen more severely damage neonatal mouse brain than mature mouse brain.
Article in Brain pathology (Zurich, Switzerland), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Histopathological and functional Characterization of a neonatal mouse model of intraventricular hemorrhage.Neuroscience · 2025Article
- Monitoring neonatal brain hemorrhage progression by photoacoustic tomography.Biomedical optics express · 2023Article
- The Regulated Cell Death and Potential Interventions in Preterm Infants after Intracerebral Hemorrhage.Current neuropharmacology · 2023Review
- Intracerebral hemorrhage and thrombin-induced alterations in cerebral microvessel matrix.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage.Frontiers in molecular neuroscience · 2022Review
- Intracerebral haemorrhage: from clinical settings to animal models.Stroke and vascular neurology · 2020Review
- Major remodeling of brain microvessels during neonatal period in the mouse: A proteomic and transcriptomic study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Cerebral microbleeds in a neonatal rat model.PloS one · 2017Article
- Third trimester-equivalent ethanol exposure causes micro-hemorrhages in the rat brain.Neuroscience · 2016Article
- Warfarin pretreatment reduces cell death and MMP-9 activity in experimental intracerebral hemorrhage.Translational stroke research · 2015Article
- Interference with protease-activated receptor 1 does not reduce damage to subventricular zone cells of immature rodent brain following exposure to blood or blood plasma.Journal of negative results in biomedicine · 2015Article
- Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.Current medicinal chemistry · 2015Review
- Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage.Translational stroke research · 2012Article
- Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema.Neurochemistry international · 2010Article
- Mechanisms of injury to white matter adjacent to a large intraventricular hemorrhage in the preterm brain.Journal of clinical ultrasound : JCU · 2010Review
- Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Does thrombin play a role in the pathogenesis of brain damage after periventricular hemorrhage?Brain pathology (Zurich, Switzerland) · 2005Article
- Experimental animal models and evaluation techniques in intracerebral hemorrhage.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of brain cell injury associated with intracerebral hemorrhage may be in part related to proteolytic enzymes in blood, some of which are also functional in the developing brain. We hypothesized that there would be an age-dependent brain response following intracerebral injection of blood, thrombin, and plasminogen. Mice at 3 ages (neonatal, 10-day-old, and young adult) received autologous blood (15, 25, and 50 microl respectively), thrombin (3, 5, and 10 units respectively), plasminogen (0.03, 0.05, and 0.1 units respectively) (the doses expected in same volume blood), or saline injection into lateral striatum. Forty-eight hours later they were perfusion fixed. Hematoxylin and eosin, lectin histochemistry, Fluoro-Jade, and TUNEL staining were used to quantify changes related to the hemorrhagic lesion. Damage volume, dying neurons, neutrophils, and microglial reaction were significantly greater following injections of blood, plasminogen, and thrombin compared to saline in all three ages of mice. Plasminogen and thrombin associated brain damage was greatest in neonatal mice and, in that group unlike the other 2, greater than the damage caused by whole blood. These results suggest that the neonatal brain is relatively more sensitive to proteolytic plasma enzymes than the mature brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.