ReviewNeuroRx : the journal of the American Society for Experimental NeuroTherapeutics2005
Animal models of generalized dystonia.
Review in NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Article
- Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study.Experimental brain research · 2018Article
- How Many Types of Dystonia? Pathophysiological Considerations.Frontiers in neurology · 2018Review
- Therapeutic Use of Non-invasive Brain Stimulation in Dystonia.Frontiers in neuroscience · 2017Review
- Acute Dystonia Following a Switch in Treatment from Atomoxetine to Low-dose Aripiprazole.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Article
- Contribution of TMS and rTMS in the Understanding of the Pathophysiology and in the Treatment of Dystonia.Frontiers in neural circuits · 2016Review
- Dystonia and cerebellar degeneration in the leaner mouse mutant.Brain research · 2015Article
- Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.Progress in neurobiology · 2015Review
- Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesias.Frontiers in veterinary science · 2015Review
- Abnormal high-frequency burst firing of cerebellar neurons in rapid-onset dystonia-parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Engineering animal models of dystonia.Movement disorders : official journal of the Movement Disorder Society · 2013Review
- Article
- Limited regional cerebellar dysfunction induces focal dystonia in mice.Neurobiology of disease · 2013Article
- The mechanisms of movement control and time estimation in cervical dystonia patients.Neural plasticity · 2013Article
- IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.Frontiers in neural circuits · 2013Article
- Selective and sustained α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation in cerebellum induces dystonia in mice.The Journal of pharmacology and experimental therapeutics · 2012Article
- Climbing fiber burst size and olivary sub-threshold oscillations in a network setting.PLoS computational biology · 2012Article
- Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction.International journal of cell biology · 2012Article
- Pathological basal ganglia activity in movement disorders.Neuroscience · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Dystonia is a prevalent neurological disorder characterized by abnormal co-contractions of antagonistic muscle groups that produce twisting movements and abnormal postures. The disorder may be inherited, arise sporadically, or result from brain insult. Dystonia is a heterogeneous disorder because patients may exhibit focal or generalized symptoms associated with abnormalities in many brain regions including basal ganglia and cerebellum. Elucidating the pathogenic mechanisms underlying dystonia has therefore been challenging. Animal models of dystonia exhibit similar heterogeneity and are useful for understanding pathogenesis. The neurochemical and neurophysiological abnormalities in rodents with idiopathic generalized dystonia suggest that dysfunctional output from basal ganglia, cerebellum, or from multiple systems is the cause of motor dysfunction. Findings from drug- or toxin-induced dystonia in rodents and nonhuman primates mirror the genetic models. The parallels between dystonia in humans and animals suggest that the models will continue to prove useful in determining pathogenesis. Furthermore, detailed characterization of the existing models of dystonia and the development of new models hold promise for the identification of novel therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.