ReviewEndocrine2005
Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties-the next generation of therapeutics.
Review in Endocrine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03638687 (Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Depression, higher level of tension induction, and impaired coping strategies in response to stress in women with PCOS correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and insulin resistance.Archives of women's mental health · 2025Article
- The Underlying Mechanisms of Comorbid Anxiety and Depression Among Young Women: Evidence From Brain Structure and Hormone.Depression and anxiety · 2025Article
- Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice.Neurobiology of stress · 2023Article
- Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.Brain sciences · 2018Article
- Serum levels of GPER-1 in euthymic bipolar patients.Neuropsychiatric disease and treatment · 2018Article
- Xenogeneic Decellularized Scaffold: A Novel Platform for Ovary Regeneration.Tissue engineering. Part C, Methods · 2017Article
- Postpartum depression risk factors: A narrative review.Journal of education and health promotion · 2017Review
- Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice.BMC complementary and alternative medicine · 2014Article
- Estrous cycle and sex affect cocaine-induced behavioural changes in CD1 mice.Psychopharmacology · 2014Article
- Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.Molecular psychiatry · 2014Article
- Enduring influence of pubertal stressors on behavioral response to hormones in female mice.Hormones and behavior · 2013Review
- β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.Psychoneuroendocrinology · 2012Article
- Significant association of estrogen receptor binding site variation with bipolar disorder in females.PloS one · 2012Article
- Article
- Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.Pharmacology, biochemistry, and behavior · 2011Article
- Long-term alteration of anxiolytic effects of ovarian hormones in female mice by a peripubertal immune challenge.Hormones and behavior · 2011Article
- A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.Menopause (New York, N.Y.) · 2010Review
- Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders.CNS neuroscience & therapeutics · 2010Review
- Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.The open drug discovery journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, estrogenic effects in depression, anxiety, and neurodegenerative disorders are summarized. Moreover, preclinical findings from in vitro and animal models are discussed. There is a correlation between decreased estrogen levels (e.g., premenstrually, during the postpartum period, and perimenopausally) and increased anxiety and depressive symptoms. Several studies show beneficial effects of estrogen treatment in women with anxiety and depressive symptoms. Recent data indicate that the estrogen receptor (ER) beta appears to be a major mediator of estrogenic effects in depression and anxiety. Additionally, both preclinical and clinical findings suggest that activation of estrogen receptors have an important role in neuroprotective and neurodegenerative processes in the mammalian central nervous system (CNS).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.