ReviewMolecular neurobiology2006
The Role of Intracellular Sodium in the Regulation of NMDA-Receptor-Mediated Channel Activity and Toxicity.
Review in Molecular neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- L-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation.Frontiers in immunology · 2024Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Bicarbonate-Independent Sodium Conductance of Na/HCOCurrent issues in molecular biology · 2022Article
- Neurometabolic Evidence Supporting the Hypothesis of Increased Incidence of Type 3 Diabetes Mellitus in the 21st Century.BioMed research international · 2019Review
- Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells.Scientific reports · 2018Article
- Deletion of TRPC6 Attenuates NMDA Receptor-Mediated CaFrontiers in neuroscience · 2017Article
- Inhibition of the NMDA receptor protects the rat sciatic nerve against ischemia/reperfusion injury.Experimental and therapeutic medicine · 2016Article
- Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.Molecular brain · 2015Article
- Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.The Journal of clinical investigation · 2014Article
- Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis.British journal of pharmacology · 2013Article
- The KtrA and KtrE subunits are required for Na+-dependent K+ uptake by KtrB across the plasma membrane in Synechocystis sp. strain PCC 6803.Journal of bacteriology · 2010Article
- Glutamate receptor ion channels: structure, regulation, and function.Pharmacological reviews · 2010Review
- Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.The Journal of pharmacology and experimental therapeutics · 2010Article
- THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY.Health · 2010Article
- Na,K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Activity-dependent neuronal cell migration induced by electrical stimulation.Medical & biological engineering & computing · 2009Article
- A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).Nature chemical biology · 2008Article
- Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons.The Journal of pharmacology and experimental therapeutics · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium (Na+) is the major cation in extracellular space and, with its entry into cells, may act as a critical intracellular second messenger that regulates many cellular functions. Through our investigations of mechanisms underlying the activity-dependent regulation of N-methyl-D-aspartate (NMDA) receptors, we recently characterized intracellular Na+ as a possible signaling factor common to processes underlying the upregulation of NMDA receptors by non-NMDA glutamate channels, voltage-gated Na+ channels, and remote NMDA receptors. Furthermore, although Ca2+ influx during the activation of NMDA receptors acts as a negative feedback mechanism that downregulates NMDA receptor activity, Na+ influx provides an essential positive feedback mechanism to overcome Ca2+ -induced inhibition, thereby potentiating both NMDA receptor activity and inward Ca2+ flow. NMDA receptors may be recruited to cause excitoxicity through a Na+ -dependent mechanism. Therefore, the further characterization of mechanisms underlying the regulation of NMDA receptors by intracellular Na+ is essential to understanding activity-dependent neuroplasticity in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.