ArticleThe Plant cell2006
Elicitor-mediated oligomerization of the tobacco N disease resistance protein.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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Who cites it
109 citing papers in PubMed.
- Tobamoviruses: Advances in Molecular Biology, Host Interactions and Integrated Disease Management.Biology · 2026Review
- Metabolic Reprogramming of a Phenolic Acid by a Plant P450 Monooxygenase Reverses Bacterial Immunosuppression.Plant biotechnology journal · 2026Article
- Fine mapping and functional verification of the Cf-19 gene controlling leaf mold disease resistance in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026Review
- From perception to action: MAPKs in plant-virus interactions.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Global Transcriptomic Analysis of Inbred Lines Reveal Candidate Genes for Response to Maize Lethal Necrosis.Plants (Basel, Switzerland) · 2025Article
- Activation and Autoinhibition Mechanisms of NLR Immune Receptor Pi36 in Rice.International journal of molecular sciences · 2024Article
- Pathogen perception and signaling in plant immunity.The Plant cell · 2024Review
- The Hypersensitive Response to Plant Viruses.Viruses · 2023Review
- Contribution of Duplicated Nucleotide-Binding Leucine-Rich Repeat (NLR) Genes to Wheat Disease Resistance.Plants (Basel, Switzerland) · 2023Review
- Review
- The MAPK-Alfin-like 7 module negatively regulates ROS scavenging genes to promote NLR-mediated immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- A cluster of atypical resistance genes in soybean confers broad-spectrum antiviral activity.Plant physiology · 2022Article
- The hybrid lethality of interspecific FMolecular breeding : new strategies in plant improvement · 2022Review
- Structural basis of NLR activation and innate immune signalling in plants.Immunogenetics · 2022Review
- HSP90 Contributes toFrontiers in plant science · 2022Article
- Article
- A genome forHorticulture research · 2022Article
- NLR immune receptor RB is differentially targeted by two homologous but functionally distinct effector proteins.Plant communications · 2021Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant nucleotide binding site-leucine-rich repeat (NBS-LRR) proteins are similar to the nucleotide binding oligomerization domain (NOD) protein family in their domain structure. It has been suggested that most NOD proteins rely on ligand-mediated oligomerization for function, and we have tested this possibility with the N protein of tobacco (Nicotiana tabacum). The N gene for resistance to Tobacco mosaic virus (TMV) is a member of the Toll-interleukin receptor (TIR)-NBS-LRR class of plant disease resistance (R) genes that recognizes the helicase domain from the TMV replicase. Using transient expression followed by immunoprecipitation, we show that the N protein oligomerizes in the presence of the elicitor. The oligomerization was not affected by silencing Nicotiana benthamiana ENHANCED DISEASE SUSCEPTIBILITY1 and N REQUIREMENT GENE1 cofactors of N-mediated resistance, but it was abolished by a mutation in the P-loop motif. However, loss-of-function mutations in the RNBS-A motif and in the TIR domain retain the ability to oligomerize. From these results, we conclude that oligomerization is an early event in the N-mediated resistance to TMV.
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