ArticleAmerican journal of respiratory and critical care medicine2006
Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice.
Article in American journal of respiratory and critical care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
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- Computed Tomography of Contemporary Occupational Lung Disease: A Pictorial Review.Diagnostics (Basel, Switzerland) · 2024Review
- Differential Immunogenicity and Lung Disease-Inducing Potential ofInternational journal of molecular sciences · 2024Article
- Microbial Community Establishment, Succession, and Temporal Dynamics in an Industrial Semi-Synthetic Metalworking Fluid Operation: A 50-Week Real-Time Tracking.Microorganisms · 2024Article
- Dominant Circulating Cell-free Mycobacterial Proteins in In-use Machining Fluid and their Antigenicity Potential.Current protein & peptide science · 2024Article
- The evidence forTranslational cancer research · 2023Review
- Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.Respiratory research · 2021Article
- S1PAmerican journal of respiratory cell and molecular biology · 2020Article
- Microbial contamination in water-based metalworking fluid as trigger for occupational hypersensitivity pneumonitis - development of specific IgG tools for a suspected clinical case.Allergologie select · 2020Article
- Molecular characterization of microbial communities and quantification of Mycobacterium immunogenum in metal removal fluids and their associated biofilms.Environmental science and pollution research international · 2016Article
- Non-culturable bioaerosols in indoor settings: Impact on health and molecular approaches for detection.Atmospheric environment (Oxford, England : 1994) · 2015Article
- Human monocyte-derived dendritic cells exposed to microorganisms involved in hypersensitivity pneumonitis induce a Th1-polarized immune response.Clinical and vaccine immunology : CVI · 2013Article
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- Assessment of airborne exposures and health in flooded homes undergoing renovation.Indoor air · 2012Article
- Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile.Environmental science & technology · 2012Article
- Factors influencing the microbial composition of metalworking fluids and potential implications for machine operator's lung.Applied and environmental microbiology · 2012Article
- Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model.Particle and fibre toxicology · 2011Article
- Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model.Particle and fibre toxicology · 2011Article
- Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture.Environmental science & technology · 2010Article
- Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis.Immunology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHuman cases of hypersensitivity pneumonitis (HP) have been reported among machinists for over 10 yr. Although mycobacteria have been implicated as causal agents, this has not been established in experimental studies and the mechanisms remain unclear. Other constituents of in-use metalworking fluids (MWFs) may also contribute to the development of lung disease. We investigated the potential for Mycobacterium immunogenum (MI) in MWFs to induce HP.
methodsMice were exposed intranasally for 3 wk to MI (isolated from MWFs), Saccharopolyspora rectivirgula (positive control), saline, endotoxin, MWFs spiked with endotoxin and/or MI, used MWFs, and particulate-fortified used MWFs. Responses were assessed 96 h after the last exposure.
resultsMice exposed to MI in MWFs developed lung pathology consistent with HP along with significantly more monocytes and neutrophils in lung lavage, increased CD4+/CD8+ T-lymphocyte ratio, and marked pulmonary lymphocytosis on histologic examination when compared with saline-treated control mice. Mice with Grade 2 or higher pathology (0-4 point scale) exhibited significantly elevated macrophage inflammatory protein-1alpha and IL-10 and a trend toward higher RANTES 96 h after the final dose. Endotoxin coexposure augmented lung pathology.
conclusionMWFs containing mycobacteria induced granulomatous lung lesions, peribronchiolar lymphocytosis, increased cell concentrations in lavage, and up-regulation of several cytokines. These findings are consistent with HP.
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