ArticleAmerican journal of human genetics2006
Variants associated with common disease are not unusually differentiated in frequency across populations.
Article in American journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Genetic Diversity Analysis of Risk Variants Associated with Bone and Cartilage Metabolism in Nine Mexican Subpopulations.Biomedicines · 2026Article
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.PloS one · 2022Article
- Leveraging genetic ancestry to study health disparities.American journal of physical anthropology · 2021Article
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- Ethnic differences in prevalence of Dupuytren disease can partly be explained by known genetic risk variants.European journal of human genetics : EJHG · 2019Article
- Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.Annals of human genetics · 2019Article
- Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population.Clinical interventions in aging · 2018Article
- Article
- Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.PLoS genetics · 2015Article
- Signatures of natural selection on genetic variants affecting complex human traits.Applied & translational genomics · 2013Article
- Analysis of the genetic basis of disease in the context of worldwide human relationships and migration.PLoS genetics · 2013Article
- Purifying selection modulates the estimates of population differentiation and confounds genome-wide comparisons across single-nucleotide polymorphisms.Molecular biology and evolution · 2012Article
- Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III).BMC medical genetics · 2012Article
- Genetic variation and its role in malignancy.International journal of biomedical science : IJBS · 2011Article
- Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.BMC medical genetics · 2011Article
- Recent human evolution has shaped geographical differences in susceptibility to disease.BMC genomics · 2011Article
- Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?PLoS genetics · 2011Article
- Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations.BMC medical genomics · 2010Article
- Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.PloS one · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variants that contribute to risk of common disease may differ in frequency across populations more than random variants in the genome do, perhaps because they have been exposed to population-specific natural selection. To assess this hypothesis empirically, we analyzed data from two groups of single-nucleotide polymorphisms (SNPs) that have shown reproducible (n = 9) or reported (n = 39) associations with common diseases. We compared the frequency differentiation (between Europeans and Africans) of the disease-associated SNPs with that of random SNPs in the genome. These common-disease-associated SNPs are not significantly more differentiated across populations than random SNPs. Thus, for the data examined here, ethnicity will not be a good predictor of genotype at many common-disease-associated SNPs, just as it is rarely a good predictor of genotype at random SNPs in the genome.
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