ArticleEuropean journal of clinical pharmacology2006
Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms.
Article in European journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review.Journal of the American Geriatrics Society · 2014Pooled it
- Use of proton pump inhibitors and mortality after hip fracture in a nationwide study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- A benefit-risk assessment of the use of proton pump inhibitors in the elderly.Drugs & aging · 2014Review
- Association of upper gastrointestinal symptoms with functional and clinical charateristics in elderly.World journal of gastroenterology · 2011Article
- Utilization and costs of antiepileptic drugs in the elderly: still an unsolved issue.Drugs & aging · 2009Review
- Prevalence, clinical features and avoidability of adverse drug reactions as cause of admission to a geriatric unit: a prospective study of 1756 patients.Drug safety · 2008Article
- Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly.Drugs & aging · 2007Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the prevalence of drug use by elderly outpatients in Italy and to identify the association between drug use and gastrointestinal symptoms. STUDY DESIGN AND
settingThe study was carried out by 133 general practitioners (GPs) who referred to 24 geriatric units in Italy. All consenting elderly patients seen at the GPs' offices were evaluated for gender, age, disability, current medications, and upper gastrointestinal symptoms.
resultsThe study included 5,515 elderly subjects. The prevalence of drug use was 91.6%, and the mean number of drugs taken was 2.86 per person. Both the prevalence and the mean number of drugs significantly increased with advancing age. Regarding gastrointestinal symptoms, 32.7% of patients reported at least one upper gastrointestinal symptom: 25% with indigestion syndrome, 16.2% with abdominal pain, and 14.2% with reflux symptoms. A significantly higher prevalence of symptoms was observed in females, patients who were taking a higher number of drugs, and those who had higher disability. Adjusted multivariate analysis demonstrated that the use of nonsteroidal antiinflammatory drugs, steroids, psycholeptics, diuretics, selective beta2 adrenoreceptor agonists or adrenergics, and antiplatelet drugs was significantly associated with upper gastrointestinal symptoms.
conclusionThe prevalence of drug use is very high in this elderly outpatient population. The number of drugs and the use of some specific drug classes are significantly associated with the presence of upper gastrointestinal symptoms.
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