ReviewMicrobiology (Reading, England)2006
Phenotypic switching in Cryptococcus neoformans.
Review in Microbiology (Reading, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Reversible stochastic epigenetic like silencing of the production of pulcherriminic acid in the antimicrobial antagonist Metschnikowia Pulcherrima.Scientific reports · 2024Article
- Mechanisms and Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2024Review
- Unveiling the menace: a thorough review of potential pandemic fungal disease.Frontiers in fungal biology · 2024Review
- Phenotypic Plasticity in the Productions of Virulence Factors Within and Among Serotypes in the Cryptococcus neoformans Species Complex.Mycopathologia · 2022Article
- Bursts of Genomic Instability Potentiate Phenotypic and Genomic Diversification inFrontiers in genetics · 2022Article
- The need for environmental surveillance to understand the ecology, epidemiology and impact of Cryptococcus infection in Africa.FEMS microbiology ecology · 2021Review
- Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Article
- Antifungal activity of topical microemulsion containing a thiophene derivative.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Neurovirulence of Cryptococcus neoformans determined by time course of capsule accumulation and total volume of capsule in the brain.Journal of neurovirology · 2013Article
- Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells.PloS one · 2012Article
- DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.PLoS pathogens · 2012Article
- Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo.Cellular microbiology · 2010Article
- Characterization of phenotypic switching in Cryptococcus neoformans biofilms.Mycopathologia · 2008Article
- Functional organisation of Escherichia coli transcriptional regulatory network.Journal of molecular biology · 2008Article
- Regulation of Cryptococcus neoformans capsule size is mediated at the polymer level.Eukaryotic cell · 2008Article
- New insights on the pathogenesis of invasive Cryptococcus neoformans infection.Current infectious disease reports · 2007Article
- Review
- Species in themSphereArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Phenotypic switching has been described in serotype A and D strains of Cryptococcus neoformans. It occurs in vivo during chronic infection and is associated with differential gene expression and changes in virulence. The switch involves changes in the polysaccharide capsule and cell wall that affect the yeast's ability to resist phagocytosis. In addition, the phenotypic switch variants elicit qualitatively different inflammatory responses in the host. In animal models of chronic cryptococosis, the immune response of the host ultimately determines which of the switch variants are selected and maintained. The importance of phenotypic switching is further underscored by several findings that are relevant in the setting of human disease. These include the ability of the mucoid colony variant of RC-2 (RC-2 MC) but not the smooth variant (RC-2 SM) to promote increased intracerebral pressure in a rat model of cryptococcal meningitis. Furthermore, chemotherapeutic and immunological antifungal interventions can promote the selection of the RC-2 MC variant during chronic murine infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.