ArticleGenome research2006
Strong correlation between meiotic crossovers and haplotype structure in a 2.5-Mb region on the long arm of chromosome 21.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Linkage disequilibrium and haplotype block structure in a composite beef cattle breed.BMC genomics · 2014Article
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- Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region.BMC genomics · 2011Article
- Genetic crossovers are predicted accurately by the computed human recombination map.PLoS genetics · 2010Article
- Article
- Article
- Identification of possible genetic alterations in the breast cancer cell line MCF-7 using high-density SNP genotyping microarray.Journal of carcinogenesis · 2009Article
- Copy number variation in human health, disease, and evolution.Annual review of genomics and human genetics · 2009Review
- Mechanisms for human genomic rearrangements.PathoGenetics · 2008Article
- Simulation of genomes: a review.Current genomics · 2008Article
- GENOMEPOP: a program to simulate genomes in populations.BMC bioinformatics · 2008Article
- A highly sensitive and specific system for large-scale gene expression profiling.BMC genomics · 2008Article
- Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Recombination rate estimation in the presence of hotspots.Genome research · 2007Article
- Haplotype block structure is conserved across mammals.PLoS genetics · 2006Article
- High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.PLoS genetics · 2006Article
- AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
Abstract
Although the haplotype structure of the human genome has been studied in great detail, very little is known about the mechanisms underlying its formation. To investigate the role of meiotic recombination on haplotype block formation, single nucleotide polymorphisms were selected at a high density from a 2.5-Mb region of human chromosome 21. Direct analysis of meiotic recombination by high-throughput multiplex genotyping of 662 single sperm identifies 41 recombinants. The crossovers were nonrandomly distributed within 16 small areas. All, except one, of these crossovers fall in areas where the haplotype structure exhibits breakdown, displaying a strong statistically positive association between crossovers and haplotype block breaks. The data also indicate a particular clustered distribution of recombination hotspots within the region. This finding supports the hypothesis that meiotic recombination makes a primary contribution to haplotype block formation in the human genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.