ArticleJournal of bacteriology2006
The quorum-sensing negative regulator RsaL of Pseudomonas aeruginosa binds to the lasI promoter.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 99 citations in OpenAlex.
- Identification of the Pseudomonas aeruginosa AgtR-CspC-RsaL pathway that controls Las quorum sensing in response to metabolic perturbation and Staphylococcus aureus.PLoS pathogens · 2025Article
- The collapse of cooperation during range expansion of Pseudomonas aeruginosa.Nature microbiology · 2024Article
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- The histidine kinase NahK regulates pyocyanin production through the PQS system.Journal of bacteriology · 2024Article
- RsaM: a unique dominant regulator of AHL quorum sensing in bacteria.Microbiology (Reading, England) · 2023Article
- The phage-encoded protein PIT2 impactsiScience · 2023Article
- Natural defense against multi-drug resistantRSC advances · 2023Article
- Parameters, architecture and emergent properties of theJournal of the Royal Society, Interface · 2023Article
- AIDmut-Seq: a Three-Step Method for Detecting Protein-DNA Binding Specificity.Microbiology spectrum · 2023Article
- Frequency of quorum-sensing mutations inMicrobiology (Reading, England) · 2022Article
- Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation ofmBio · 2022Article
- Antiactivators prevent self-sensing inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom.Transcription · 2021Review
- Molecular Mechanisms of Phosphate Stress Activation of Pseudomonas aeruginosa Quorum Sensing Systems.mSphere · 2020Article
- Multidrug Adaptive Resistance of Pseudomonas aeruginosa Swarming Cells.Antimicrobial agents and chemotherapy · 2020Article
- Response ofFrontiers in microbiology · 2019Article
- TwoJournal of bacteriology · 2018Article
- Differential Regulation of the Phenazine Biosynthetic Operons by Quorum Sensing inFrontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mutation in the rsaL gene of Pseudomonas aeruginosa produces dramatically higher amounts of N-acyl homoserine lactone with respect to the wild type, highlighting the key role of this negative regulator in controlling quorum sensing (QS) in this opportunistic pathogen. The DNA binding site of the RsaL protein on the rsaL-lasI bidirectional promoter partially overlaps the binding site of the LasR protein, consistent with the hypothesis that RsaL and LasR could be in binding competition on this promoter. This is the first direct demonstration that RsaL acts as a QS negative regulator by binding to the lasI promoter.
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