ArticleJournal of bacteriology2006
Expression Analysis of Up-Regulated Genes Responding to Plumbagin in Escherichia coli.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- One-carbon metabolism, folate, zinc and translation.Microbial biotechnology · 2020Article
- Sublethal Paraquat Confers Multidrug Tolerance inFrontiers in microbiology · 2020Article
- Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery.Scientific reports · 2019Article
- Proteomics analyses of Bacillus subtilis after treatment with plumbagin, a plant-derived naphthoquinone.Omics : a journal of integrative biology · 2015Article
- Superoxide-mediated protection of Escherichia coli from antimicrobials.Antimicrobial agents and chemotherapy · 2013Article
- YihE kinase is a central regulator of programmed cell death in bacteria.Cell reports · 2013Article
- YgfZ contributes to secretion of cytotoxic necrotizing factor 1 into outer-membrane vesicles in Escherichia coli.Microbiology (Reading, England) · 2012Article
- Evidence that the folate-dependent proteins YgfZ and MnmEG have opposing effects on growth and on activity of the iron-sulfur enzyme MiaB.Journal of bacteriology · 2012Article
- Synergistic use of plant-prokaryote comparative genomics for functional annotations.BMC genomics · 2011Article
- A role of ygfZ in the Escherichia coli response to plumbagin challenge.Journal of biomedical science · 2010Article
- A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plumbagin is found in many medicinal plants and has been reported to have antimicrobial activities. We examined the molecular responses of Escherichia coli to plumbagin by using a proteomic approach to search for bacterial genes up-regulated by the drug. The protein profile obtained was compared with that of E. coli without the plumbagin treatment. Subsequent analyses of the induced proteins by mass spectroscopy identified several up-regulated genes, including ygfZ, whose function has not been defined. Analyses of the 5'-flanking sequences indicate that most of these genes contain a marbox-like stretch, and several of them are categorized as members of the mar/sox regulon. Representatives of these genes were cloned into plasmids, and the marbox-like sequences were modified by site-directed mutagenesis. It was proven that mutations in these regions substantially repressed the level of proteins encoded by the downstream genes. Furthermore, plumbagin's early effect was demonstrated to robustly induce SoxS rather than MarA, an observation distinctly different from that seen with sodium salicylate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.