ArticleProtein science : a publication of the Protein Society2006
High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.
Article in Protein science : a publication of the Protein Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder.Molecular psychiatry · 2006Trial
- Binding Behavior of Human Hepatoma-Derived Growth Factor onThe journal of physical chemistry. B · 2024Article
- Histone Readers and Their Roles in Cancer.Cancer treatment and research · 2023Article
- H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function.Nucleic acids research · 2022Article
- A novel function of HRP-3 in regulating cell cycle progression via the HDAC-E2F1-Cyclin E pathway in lung cancer.Cancer science · 2022Article
- The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin.Nucleic acids research · 2019Article
- Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains.Molecules (Basel, Switzerland) · 2018Review
- Multiple solution structures of the disordered peptide indolicidin from IMS-MS analysis.International journal of mass spectrometry · 2018Article
- Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor.Scientific reports · 2018Article
- Hepatoma-derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2016Article
- SETD2: an epigenetic modifier with tumor suppressor functionality.Oncotarget · 2016Review
- PWWP domains and their modes of sensing DNA and histone methylated lysines.Biophysical reviews · 2016Review
- Touch, act and go: landing and operating on nucleosomes.The EMBO journal · 2016Review
- Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer.Oncotarget · 2015Article
- Molecular mechanisms of MLL-associated leukemia.International journal of hematology · 2015Review
- Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.Epigenetics & chromatin · 2013Article
- Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.Nucleic acids research · 2013Article
- TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.PloS one · 2013Article
- DNA methylation pattern as important epigenetic criterion in cancer.Genetics research international · 2013Review
- Evolution of the PWWP-domain encoding genes in the plant and animal lineages.BMC evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear-targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70-amino acid motif, originally identified from the WHSC1 gene, has been found in more than 60 eukaryotic proteins. In addition to the PWWP domain, many proteins in this class contain known chromatin remodeling domains, suggesting a role for HDGF in chromatin remodeling. We have determined the NMR structure of the HDGF PWWP domain to high resolution using a combination of NOEs, J-couplings, and dipolar couplings. Comparison of this structure to a previously determined structure of the HDGF PWWP domain shows a significant difference in the C-terminal region. Comparison to structures of other PWWP domains shows a high degree of similarity to the PWWP domain structures from Dnmt3b and mHRP. The results of selected and amplified binding assay and NMR titrations with DNA suggest that the HDGF PWWP domain may function as a nonspecific DNA-binding domain. Based on the NMR titrations, we propose a model of the interaction of the PWWP domain with DNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.