ArticleMolecular and cellular biology2006
The G-protein-coupled receptor GPR103 regulates bone formation.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.Nature communications · 2024Article
- Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.Cell discovery · 2024Article
- The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.PloS one · 2022Article
- The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.Journal of clinical laboratory analysis · 2021Article
- Transcriptome Remodeling in Gradual Development of Inverse Resistance between Paclitaxel and Cisplatin in Ovarian Cancer Cells.International journal of molecular sciences · 2020Article
- Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer.Oncology reports · 2019Article
- The role of GPCRs in bone diseases and dysfunctions.Bone research · 2019Review
- The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24.British journal of pharmacology · 2017Review
- Attacking sleep from a new angle: contributions from zebrafish.Current opinion in neurobiology · 2017Review
- Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function.Frontiers in endocrinology · 2017Review
- QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies.British journal of pharmacology · 2014Article
- RFamide Peptides in Early Vertebrate Development.Frontiers in endocrinology · 2014Review
- Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents.Frontiers in endocrinology · 2014Review
- Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice.Journal of lipid research · 2010Article
- GPR103b functions in the peripheral regulation of adipogenesis.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse.Genomics · 2009Review
- Neuropeptide Y Y2 receptor in health and disease.British journal of pharmacology · 2008Review
- Nuclear factor I X deficiency causes brain malformation and severe skeletal defects.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GPR103 is a G-protein-coupled receptor with reported expression in brain, heart, kidney, adrenal gland, retina, and testis. It encodes a 455-amino-acid protein homologous to neuropeptide FF2, neuropeptide Y2, and galanin GalR1 receptors. Its natural ligand was recently identified as 26RFa, a novel human RF-amide-related peptide with orexigenic activity. To identify the function of GPR103, we generated GPR103-deficient mice. Homozygous mutant mice were viable and fertile. Their body weight was undistinguishable from that of their wild-type littermates. Histological analysis revealed that GPR103-/- mice exhibited a thinned osteochondral growth plate, a thickening of trabecular branches, and a reduction in osteoclast number, suggestive of an early arrest of osteochondral bone formation. Microcomputed tomography confirmed the reduction in trabecular bone and connective tissue densities in GPR103 knockout animals. Whole-body radiography followed by morphometric analysis revealed a kyphosis in mutant animals. Reverse transcription-PCR analysis showed that GPR103 was expressed in human skull, mouse spine, and several osteoblast cell lines. Dexamethasone, a known inhibitor of osteoblast growth and inducer of osteoblast differentiation, inhibited GPR103 expression in human osteoblast primary cultures. Altogether, these results suggest that osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone.
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