ArticleMolecular and cellular biology2006
Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres.DNA repair · 2013Article
- Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics.Nucleic acids research · 2013Article
- Dss1 release activates DNA binding potential in Brh2.Biochemistry · 2012Article
- Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation.Molecular microbiology · 2011Article
- Mutational analysis of Brh2 reveals requirements for compensating mediator functions.Molecular microbiology · 2011Article
- Dss1 regulates interaction of Brh2 with DNA.Biochemistry · 2009Article
- Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis.DNA repair · 2009Article
- DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA.The Journal of biological chemistry · 2009Article
- The homologous recombination system of Ustilago maydis.Fungal genetics and biology : FG & B · 2008Review
- Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination.Molecular microbiology · 2008Article
- D-loop formation by Brh2 protein of Ustilago maydis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae.BMC genomics · 2007Article
- Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis.DNA repair · 2007Article
- Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Rec2 is the single Rad51 paralog in Ustilago maydis. Here, we find that Rec2 is required for radiation-induced Rad51 nuclear focus formation but that Rec2 foci form independently of Rad51 and Brh2. Brh2 foci also form in the absence of Rad51 and Rec2. By coprecipitation from cleared extracts prepared from Escherichia coli cells expressing the proteins, we found that Rec2 interacts physically not only with Rad51 and itself but also with Brh2. Transgenic expression of Brh2 in rec2 mutants can effectively restore radiation resistance, but the frequencies of spontaneous Rad51 focus formation and allelic recombination are elevated. The Dss1-independent Brh2-RPA70 fusion protein is also active in restoring radiation sensitivity of rec2 but is hyperactive to an extreme degree in allelic recombination and in suppressing the meiotic block of rec2. However, the high frequency of chromosome missegregation in meiotic products is an indicator of a corrupted process. The results demonstrate that the importance of Rec2 function is not only in stimulating recombination activity but also in ensuring that recombination is properly controlled.
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Registered trials
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