ArticleMolecular biology of the cell2006
Rck2 is required for reprogramming of ribosomes during oxidative stress.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
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- Nanopore Direct RNA Sequencing of Monosome- and Polysome-Bound RNA.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan.Aging · 2021Article
- Identifying the Translatome of Mouse NEBD-Stage Oocytes via SSP-Profiling; A Novel Polysome Fractionation Method.International journal of molecular sciences · 2020Article
- Introns provide a platform for intergenic regulatory feedback of RPL22 paralogs in yeast.PloS one · 2018Article
- Circadian clock regulation of mRNA translation through eukaryotic elongation factor eEF-2.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Stress-induced inhibition of translation independently of eIF2α phosphorylation.Journal of cell science · 2015Article
- The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans.Eukaryotic cell · 2015Article
- Article
- The Saccharomyces cerevisiae Hot1p regulated gene YHR087W (HGI1) has a role in translation upon high glucose concentration stress.BMC molecular biology · 2012Article
- Global regulation of gene expression by OxyR in an important human opportunistic pathogen.Nucleic acids research · 2012Article
- Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast.Genome biology · 2012Article
- Review
- Cellular stress induces cytoplasmic RNA granules in fission yeast.RNA (New York, N.Y.) · 2011Article
- The HOG pathway dictates the short-term translational response after hyperosmotic shock.Molecular biology of the cell · 2010Article
- Minimization of biosynthetic costs in adaptive gene expression responses of yeast to environmental changes.PLoS computational biology · 2010Article
- mRNA stability changes precede changes in steady-state mRNA amounts during hyperosmotic stress.RNA (New York, N.Y.) · 2009Article
- Yeast translational response to high salinity: global analysis reveals regulation at multiple levels.RNA (New York, N.Y.) · 2008Article
- Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.Eukaryotic cell · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rck2 is a mitogen-activated protein kinase-activated protein kinase in yeast implicated in translational regulation. rck2Delta mutants are mildly sensitive to oxidative stress, a condition that causes dissociation of actively translating ribosomes (polysomes). In rck2Delta cells, polysomes are lost to an even higher degree than in the wild-type upon stress. Cells overexpressing the catalytically inactive rck2-kd allele are highly sensitive to oxidative stress. In such cells, dissociation of polysomes upon stress was instead greatly delayed. The protein synthesis rate decreased to a similar degree as in wild-type cells, however, indicating that in rck2-kd cells, the polysome complexes were inactive. Array analyses of total and polysome-associated mRNAs revealed major deregulation of the translational machinery in rck2 mutant cells. This involves transcripts for cytosolic ribosomal proteins and for processing and assembly of ribosomes. In rck2Delta cells, weakly transcribed mRNAs associate more avidly with polysomes than in wild-type cells, whereas the opposite holds true for rck2-kd cells. This is consistent with perturbed regulation of translation elongation, which is predicted to alter the ratio between mRNAs with and without strong entry sites at ribosomes. We infer that imbalances in the translational apparatus are a major reason for the inability of these cells to respond to stress.
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