ArticleAmerican journal of human genetics2005
Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.European journal of human genetics : EJHG · 2010Pooled it
- Meta-analysis of genome-wide linkage studies of asthma and related traits.Respiratory research · 2008Pooled it
- Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans.Genome biology · 2023Article
- Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity.Cell discovery · 2018Article
- A time-varying group sparse additive model for genome-wide association studies of dynamic complex traits.Bioinformatics (Oxford, England) · 2016Article
- Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia.PloS one · 2015Article
- An understanding of the genetic basis of asthma.The Indian journal of medical research · 2011Review
- Genetic and environmental contributions to allergen sensitization in a Chinese twin study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Article
- Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.European journal of human genetics : EJHG · 2009Article
- Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12.Immunogenetics · 2009Article
- Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.American journal of respiratory and critical care medicine · 2008Article
- Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families.Human genetics · 2007Article
- Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica.Thorax · 2007Article
- Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica.Human genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 30 genomic regions show linkage to asthma traits. Six asthma genes have been cloned, but the putative loci in many linked regions have not been identified. To search for asthma susceptibility loci, we performed genomewide univariate linkage analyses of seven asthma traits, using 202 Australian families ascertained through a twin proband. House-dust mite sensitivity (Dpter) exceeded the empirical threshold for significant linkage at 102 cM on chromosome 20q13, near marker D20S173 (empirical pointwise P = .00001 and genomewide P = .005, both uncorrected for multiple-trait testing). Atopy, bronchial hyperresponsiveness (BHR), and forced expiratory volume in 1 s (FEV1) were also linked to this region. In addition, 16 regions were linked to at least one trait at the suggestive level, including 12q24, which has consistently shown linkage to asthma traits in other studies. Some regions were expected to be false-positives arising from multiple-trait testing. To address this, we developed a new approach to estimate genomewide significance that accounts for multiple-trait testing and for correlation between traits and that does not require a Bonferroni correction. With this approach, Dpter remained significantly linked to 20q13 (empirical genomewide P = .042), and airway obstruction remained linked to 12q24 at the suggestive level. Finally, we extended this method to show that the linkage of Dpter, atopy, BHR, FEV1, asthma, and airway obstruction to chromosome 20q13 is unlikely to be due to chance and may result from a quantitative trait locus in this region that affects several of these traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.