ArticleAmerican journal of human genetics2005
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.Current medical science · 2018Pooled it
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Characterization of Behavioral Phenotypes in Heterozygous DAT Rat Based on Pedigree.Biomedicines · 2023Article
- Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders.Journal of neuroinflammation · 2022Article
- A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.Frontiers in genetics · 2022Article
- DNA methylation of dopamine-related gene promoters is associated with line bisection deviation in healthy adults.Scientific reports · 2019Article
- ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.Pediatric research · 2016Article
- Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families.Molecular autism · 2016Article
- Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?Behavioral and brain functions : BBF · 2015Review
- Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.Iranian journal of reproductive medicine · 2015Article
- Article
- Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.Genes, brain, and behavior · 2014Article
- Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Family-based association analysis of serotonin genes in pathological gambling disorder: evidence of vulnerability risk in the 5HT-2A receptor gene.Journal of molecular neuroscience : MN · 2013Article
- Attention deficit/hyperactivity disorder symptoms and depression symptoms as mediators in the intergenerational transmission of smoking.Drug and alcohol dependence · 2012Article
- The genetics of attention deficit/hyperactivity disorder in adults, a review.Molecular psychiatry · 2012Review
- Preliminary evaluation after setting up a post-assessment attention deficit hyperactivity disorder clinic in a community setting.Irish journal of medical science · 2012Article
- Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder.Journal of psychiatry & neuroscience : JPN · 2012Article
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10 authors at 1 institution in 1 country.
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Abstract
Family, twin, and adoption studies have demonstrated a significant genetic contribution to the etiology of attention-deficit/hyperactivity disorder (ADHD). Pharmacological, neuroimaging, and animal-model findings suggest imbalances in monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in ADHD. We have examined monoaminergic candidate genes for possible genetic association with ADHD in the Irish population, focusing particularly on genes of the dopaminergic and serotonergic systems. We have observed that several of these genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5, and 5HT1B. Here, we present what appears to be a systematic overtransmission of paternal alleles at candidate genes associated with ADHD. For the nine genes included in the analysis, the overall odds ratio for paternal transmission was 2, compared with 1.3 for maternal transmission (paternal vs. maternal chi 2=9.6; P=.0019). Transmission to females, from either parent, was significantly stronger than to males. Possible reasons for this preferential transmission include imprinting and ascertainment bias, although results of further analyses show that the latter is unlikely.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.