Evidence map›Paper›PMID 16380816›Full record

ReviewJournal of clinical immunology2005

V alpha14 i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes.

Yuki Kinjo, Mitchell Kronenberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  7. Immune evasion of the CD1d/NKT cell axis.Current opinion in immunology · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuki KinjoDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Mitchell Kronenberg
La Jolla Institute for Immunology · US

Funding

Recognition of bacterial antigens by NKT cellsR01AI045053 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2000 to 2010
$3.3M
NCI NIH HHS CA 52511NIAID NIH HHS AI 45053
6 · The paper itself

Abstract

Natural Killer T (NKT) cells constitute a conserved T lymphocyte sublineage that has been implicated in the regulation of various immune responses, including the responses to viruses, bacteria, and parasites. NKT cells recognize self and foreign glycolipids presented by CD1d, a non-classical antigen-presenting molecule, and they rapidly produce various cytokines. Many studies have shown that NKT cells have protective roles following microbial infection through the amplification of innate and adaptive immunity, although NKT cells have detrimental roles in some cases. Recent studies have shed light on the natural antigens recognized by NKT cells and the mechanisms whereby they contribute to host defense, and they suggest that these unique T cells have evolved to jump start the immune response to microbes.

Indexed as

Immunity, InnateAnimalsBacterial InfectionsGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorHumansNatural Killer T-CellsProtozoan InfectionsReceptors, Antigen, T-Cell, alpha-betaVirus DiseasesReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID16380816
OpenAlexW2037425278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.