ArticleAmerican journal of physiology. Renal physiology2006
Megalin binds and internalizes angiotensin-(1-7).
Article in American journal of physiology. Renal physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms.Genes & diseases · 2026Review
- Cryo-EM structures elucidate the multiligand receptor nature of megalin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023Article
- Identification of Potential Megalin/Cubilin Substrates Using Extensive Proteomics Quantification from Kidney Megalin-Knockdown Mice.The AAPS journal · 2022Article
- Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.American journal of physiology. Renal physiology · 2020Article
- Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism.Cellular and molecular life sciences : CMLS · 2018Article
- Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal Tubules.International journal of molecular sciences · 2016Article
- Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2015Article
- Intracellular angiotensin (1-7) increases the inward calcium current in cardiomyocytes. On the role of PKA activation.Molecular and cellular biochemistry · 2015Article
- Reply to "measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?".Antimicrobial agents and chemotherapy · 2014Article
- Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin.American journal of physiology. Renal physiology · 2014Article
- Female spontaneously hypertensive rats are more dependent on ANG (1-7) to mediate effects of low-dose AT1 receptor blockade than males.American journal of physiology. Renal physiology · 2014Article
- Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways.Frontiers in endocrinology · 2014Review
- Resistance to insulin and kidney disease in the cardiorenal metabolic syndrome; role for angiotensin II.Molecular and cellular endocrinology · 2013Review
- Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats.American journal of hypertension · 2013Article
- Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney.Peptides · 2012Article
- Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- Novel roles of nuclear angiotensin receptors and signaling mechanisms.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease.Frontiers in physiology · 2012Article
- Angiotensin (1-7) induces MAS receptor internalization.Hypertension (Dallas, Tex. : 1979) · 2011Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Megalin is a multiligand receptor heavily involved in protein endocytosis. We recently demonstrated that megalin binds and mediates internalization of ANG II. Although there is a strong structural resemblance between ANG II and ANG-(1-7), their physiological actions and their affinity for the angiotensin type 1 receptor (AT(1)R) are dissimilar. Therefore, the hypothesis of the present work was to test whether megalin binds and internalizes ANG-(1-7). The uptake of ANG-(1-7) was determined by exposure of confluent monolayers of BN/MSV cells (a model representative of the yolk sac epithelium) to fluorescently labeled ANG-(1-7) (100 nM) and measurement of the amount of cell-associated fluorescence after 4 h by flow cytometry. Anti-megalin antisera and an AT(1)R blocker (olmesartan) were used to interfere with uptake via megalin and the AT(1)R, respectively. ANG-(1-7) uptake was prevented by anti-megalin antisera (63%) to a higher degree than olmesartan (13%) (P < 0.001). In analysis by flow cytometry of binding experiments performed in brush-border membrane vesicles isolated from kidneys of CD-1 mice, anti-megalin antisera interfered with ANG-(1-7) binding more strongly than olmesartan (P < 0.05 against positive control). Interactions of megalin with ANG-(1-7) at a molecular level were studied by surface plasmon resonance, demonstrating that ANG-(1-7) binds megalin dose and time dependently and with an affinity similar to ANG II. These results show that the scavenger receptor megalin binds and internalizes ANG-(1-7).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.