ArticleThe Journal of general physiology2006
Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Optogenetic Activation of Type III Taste Cells Modulates Taste Responses.Chemical senses · 2020Article
- The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models.Journal of neurophysiology · 2013Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli.Journal of neurophysiology · 2012Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.Journal of neurophysiology · 2012Article
- Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.Chemical senses · 2011Article
- The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli.Chemical senses · 2011Article
- Sour taste responses in mice lacking PKD channels.PloS one · 2011Article
- Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin.Journal of neurophysiology · 2009Article
- The hydrogel nature of mammalian cytoplasm contributes to osmosensing and extracellular pH sensing.Biophysical journal · 2009Article
- Cracking taste codes by tapping into sensory neuron impulse traffic.Progress in neurobiology · 2008Review
- Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste.The Journal of physiology · 2008Article
- Inhibition of eryptosis and intraerythrocytic growth of Plasmodium falciparum by flufenamic acid.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
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7 authors.
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Abstract
The relationship between cell volume and the neural response to acidic stimuli was investigated by simultaneous measurements of intracellular pH (pHi) and cell volume in polarized fungiform taste receptor cells (TRCs) using 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF) in vitro and by rat chorda tympani (CT) nerve recordings in vivo. CT responses to HCl and CO2 were recorded in the presence of 1 M mannitol and specific probes for filamentous (F) actin (phalloidin) and monomeric (G) actin (cytochalasin B) under lingual voltage clamp. Acidic stimuli reversibly decrease TRC pHi and cell volume. In isolated TRCs F-actin and G-actin were labeled with rhodamine phalloidin and bovine pancreatic deoxyribonuclease-1 conjugated with Alexa Fluor 488, respectively. A decrease in pHi shifted the equilibrium from F-actin to G-actin. Treatment with phalloidin or cytochalasin B attenuated the magnitude of the pHi-induced decrease in TRC volume. The phasic part of the CT response to HCl or CO2 was significantly decreased by preshrinking TRCs with hypertonic mannitol and lingual application of 1.2 mM phalloidin or 20 microM cytochalasin B with no effect on the tonic part of the CT response. In TRCs first treated with cytochalasin B, the decrease in the magnitude of the phasic response to acidic stimuli was reversed by phalloidin treatment. The pHi-induced decrease in TRC volume induced a flufenamic acid-sensitive nonselective basolateral cation conductance. Channel activity was enhanced at positive lingual clamp voltages. Lingual application of flufenamic acid decreased the magnitude of the phasic part of the CT response to HCl and CO2. Flufenamic acid and hypertonic mannitol were additive in inhibiting the phasic response. We conclude that a decrease in pHi induces TRC shrinkage through its effect on the actin cytoskeleton and activates a flufenamic acid-sensitive basolateral cation conductance that is involved in eliciting the phasic part of the CT response to acidic stimuli.
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