SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2005
Topical antibiotics for acute bacterial conjunctivitis: Cochrane systematic review and meta-analysis update.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Antibiotics versus placebo for acute bacterial conjunctivitis.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Bacterial conjunctivitis.BMJ clinical evidence · 2012Pooled it
- Bacterial conjunctivitis.BMJ clinical evidence · 2010Pooled it
- A randomised controlled trial of management strategies for acute infective conjunctivitis in general practice.BMJ (Clinical research ed.) · 2006Trial
- In Vitro Bactericidal Activity of Propamidine 0.1% and Other Ophthalmic Antiseptics on Conjunctivitis and Blepharitis Strains.Ophthalmology and therapy · 2026Article
- Therapeutic efficacy of different routes of mesenchymal stem cell administration in corneal injury.The ocular surface · 2019Article
- Observational
- Adult bacterial conjunctivitis: resistance patterns over 12 years in patients attending a large primary eye care centre in the UK.BMJ open ophthalmology · 2017Article
- Cochrane systematic reviews and co-publication: dissemination of evidence on interventions for ophthalmic conditions.Systematic reviews · 2015Article
- Interdisciplinary workshop in the philosophy of medicine: medical knowledge, medical duties.Journal of evaluation in clinical practice · 2014Review
- The influence of children's day care on antibiotic seeking: a mixed methods study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2014Article
- A European perspective on topical ophthalmic antibiotics: current and evolving options.Ophthalmology and eye diseases · 2011Article
- Clinical use of gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis.Clinical ophthalmology (Auckland, N.Z.) · 2011Article
- Shifting trends in in vitro antibiotic susceptibilities for common bacterial conjunctival isolates in the last decade at the New York Eye and Ear Infirmary.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
- Effectiveness, tolerability and safety of azithromycin 1% in DuraSite for acute bacterial conjunctivitis.Patient preference and adherence · 2010Article
- Patterns of eye care use and expenditures among children with diagnosed eye conditions.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2007Article
- Antibiotics for upper respiratory tract infections and conjunctivitis in primary care.BMJ (Clinical research ed.) · 2006Article
- Non-bacterial acute conjunctivitis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncertainty remains about the extent to which findings from our previously published systematic review and meta-analysis of double-blind, randomised controlled trials of topical antibiotics compared with placebo in the management of patients with acute bacterial conjunctivitis treated in secondary care outpatient settings are generalisable to the management of the condition in primary care settings. We updated our review, undertaking searches, methodological assessment, data extraction and analysis according to a pre-defined protocol. In addition to the previous three included studies, we identified two additional double-blind primary care trials, one which compares fusidic acid gel with placebo gel and one which compares chloramphenicol eye drops with placebo eye drops in children. Meta-analyses of clinical and microbiological remission data reveal that topical antibiotics are of benefit in improving early (days 2-5) clinical (relative risk [RR] = 1.24, 95% confidence interval [CI] = 1.05 to 1.45) and microbiological (RR = 1.77, 95% CI = 1.23 to 2.54) remission rates; later (days 6-10) data reveal that these early advantages in clinical (RR = 1.11, 95% CI = 1.02 to 1.21) and microbiological cure rates are reduced (RR 1.56, 95% CI = 1.17 to 2.09), but persist. Most cases of acute bacterial conjunctivitis resolve spontaneously. While topical antibiotics are associated with significantly improved rates of early (days 2-5) clinical remission, this benefit is marginal for later remission (days 6-10).
Indexed as
Identifiers
16378567PMC1570513W1767513691What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.