ArticleDiabetologia2006
Does the new International Diabetes Federation definition of the metabolic syndrome predict CHD any more strongly than older definitions? Findings from the British Women's Heart and Health Study.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Pooled it
- Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review.PLoS medicine · 2010Pooled it
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- Role of gender in explaining metabolic syndrome risk factors in an Iranian rural population using structural equation modelling.Scientific reports · 2023Article
- Metabolic Syndrome and Cardiometabolic Risk Factors in the Mixed Hypercholesterolemic Populations with Respect to Gender, Age, and Obesity in Asir, Saudi Arabia.International journal of environmental research and public health · 2022Article
- The Cardiovascular and Cerebrovascular Health in North China From 2006 to 2011: Results From the KaiLuan Study.Frontiers in cardiovascular medicine · 2021Article
- Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort.Cardiovascular diabetology · 2020Article
- Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang.PloS one · 2018Article
- Which Components of Metabolic Syndrome have a Greater Effect on Mortality, CVA and Myocardial Infarction, Hyperglycemia, High Blood Pressure or Both?Advanced biomedical research · 2017Article
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- Relationship between nocturnal blood pressure and 24-h urinary sodium excretion in a rural population in Korea.Clinical hypertension · 2014Article
- Diversity of metabolic syndrome criteria in association with cardiovascular diseases--a family medicine-based investigation.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Within-visit blood pressure variability: relevant factors in the general population.Journal of human hypertension · 2013Article
- Change in HbA1c over 3 years does not improve the prediction of cardiovascular disease over and above HbA1c measured at a single time point.Diabetologia · 2013Article
- Clinical usefulness of the metabolic syndrome for the risk of coronary heart disease does not exceed the sum of its individual components in older men and women. The Three-City (3C) Study.Heart (British Cardiac Society) · 2012Article
- A gender-stratified comparative analysis of various definitions of metabolic syndrome and cardiovascular risk in a multiethnic U.S. population.Metabolic syndrome and related disorders · 2012Article
- An exploratory analysis of dynamic change of metabolic syndrome in relation to the risk of developing cardiovascular disease in a chinese cohort.Iranian journal of public health · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe compared the associations between three definitions of the metabolic syndrome and CHD risk. The definitions studied were the new International Diabetes Federation (IDF) definition, and those of the World Health Organization (WHO) and the National Cholesterol Education Programme (NCEP). Our aim was to determine whether the magnitudes of the associations for any of the syndrome definitions are greater than for the individual components. MATERIALS AND
methodsA prospective cohort study of a random sample of 3,589 British women who were aged 60-79 years and free of CHD at baseline was performed. Among these women there were 194 incident cases of CHD (40 of them fatal) during 15,778 woman-years of follow-up.
resultsInsulin resistance (homeostasis model assessment), triglyceride levels, systolic blood pressure, waist and waist-to-hip ratio were positively and linearly associated with CHD risk; HDL cholesterol was inversely associated with risk. All three definitions of the metabolic syndrome were modestly and similarly (to each other) associated with CHD risk. The age-adjusted hazard ratio (95% CI) was 1.32 (1.03, 1.70) for IDF syndrome, 1.45 (1.00, 2.10) for WHO syndrome, and 1.38 (1.00, 1.93) for NCEP syndrome. Adjustment for smoking, inactivity and life-course socioeconomic position resulted in attenuation of these associations to 1.25 (0.96, 1.61), 1.31 (0.90, 1.90) and 1.27 (0.90, 1.79), respectively. The magnitudes of the associations for individual components of the syndrome were similar to those for any of the syndrome definitions. CONCLUSIONS/
interpretationThe metabolic syndrome, defined by any of the three methods, is only modestly associated with CHD risk in this study of older women. Life-course socioeconomic position appears to be an important confounder in the association of the metabolic syndrome with CHD risk.
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