ArticleAntimicrobial agents and chemotherapy2006
Different modes of action of naphthyridones in gram-positive and gram-negative bacteria.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Nanopore sequencing reveals operon-specific ribosome remodeling accompanying naphthyridone resistance inbioRxiv : the preprint server for biology · 2025Article
- Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening.Journal of bacteriology · 2015Article
- A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria.Antimicrobial agents and chemotherapy · 2014Article
- The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.The Journal of biological chemistry · 2014Article
- Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.Journal of bacteriology · 2012Article
- Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase.ACS medicinal chemistry letters · 2012Article
- In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.The Journal of biological chemistry · 2011Article
- Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.