ArticleThe Journal of comparative neurology2006
Developmental period for N-methyl-D-aspartate (NMDA) receptor-dependent synapse elimination correlated with visuotopic map refinement.
Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Role of NMDAR plasticity in a computational model of synaptic memory.Scientific reports · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Uncorrelated Neural Firing in Mouse Visual Cortex during Spontaneous Retinal Waves.Frontiers in cellular neuroscience · 2017Article
- Synaptic plasticity in the facial nucleus in rats following infraorbital nerve manipulation after facial nerve injury.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period.Scientific reports · 2016Article
- On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors.Biomolecules · 2015Review
- Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.Molecular pharmacology · 2015Review
- AMPA-silent synapses in brain development and pathology.Nature reviews. Neuroscience · 2013Review
- Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition.Journal of neurophysiology · 2013Article
- Monosynaptic convergence of chorda tympani and glossopharyngeal afferents onto ascending relay neurons in the nucleus of the solitary tract: a high-resolution confocal and correlative electron microscopy approach.The Journal of comparative neurology · 2013Article
- Auditory experience refines cortico-basal ganglia inputs to motor cortex via remapping of single axons during vocal learning in zebra finches.Journal of neurophysiology · 2012Article
- Article
- Article
- Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PDZ protein mediated activity-dependent LTP/LTD developmental switch at rat retinocollicular synapses.American journal of physiology. Cell physiology · 2010Article
- "Slow activity transients" in infant rat visual cortex: a spreading synchronous oscillation patterned by retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
During a short perinatal interval, N-methyl-D-aspartate receptor (NMDAR) function is essential to a process in which spontaneous retinal waves focus retinal axon arbors in the superficial layers of the rodent superior colliculus (sSC). Here we provide evidence that this NMDAR-dependent axonal refinement occurs through elimination of uncorrelated retinal synapses arising from disparate loci, rather than stabilization of topographically appropriate inputs. The density of synaptic release sites within fluorescently labeled retinal terminals was counted in double-labeling experiments using confocal microscopy and antibodies against synaptophysin or synapsin-1. Chronic NMDAR blockade from birth increased retinal axon synapse density at postnatal days (P) 6, 8, and 10, suggesting that NMDAR currents reduce synapse density during the refinement period. With assay at P14, after focal arborization has been established, the effect disappeared. Conversely, chronic NMDA treatment, known to induce functional synaptic depression in the sSC, decreased retinocollicular synapse density at P14, but not earlier, during the refinement period (P8). Thus during the development of retinocollicular topographic order, there is a period when NMDAR activity predominantly eliminates retinal axon synapses. We were able to extend this period by using retinal lesions to reduce synaptic density in a defined zone. Synapse density on intact retinocollicular axons sprouting into this zone was increased by NMDAR blockade, even when examined at P14. Thus, the period of NMDAR-dependent synaptic destabilization is terminated by a factor related to the density and refinement of retinal arbors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.