ReviewDer Orthopade2006
[Therapy of arthrofibrosis after total knee arthroplasty].
Review in Der Orthopade, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- [Diagnostic strategies in cases of suspected periprosthetic infection of the knee. A review of the literature and current recommendations].Der Orthopade · 2006Pooled it
- Vitamin C demand is increased after total knee arthroplasty: a double-blind placebo-controlled-randomized study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Trial
- Manipulation under anaesthesia versus low stretch device in poor range of motion after TKA.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Trial
- Conservative treatment of knee arthrofibrosis according to a cellular cytokine-based model : A retrospective pilot evaluation.Wiener klinische Wochenschrift · 2025Article
- [Histopathological diagnostics of arthrofibrosis].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- [Clinical diagnostics, differential diagnostics, pathogenesis and stage model of arthrofibrosis].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study.Journal of experimental orthopaedics · 2022Article
- Causes of knee pain evaluated by arthroscopy after knee arthroplasty: a case series.International orthopaedics · 2022Article
- Arthrofibrosis after total knee arthroplasty: patients with keloids at risk.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021Article
- Literature review of the causes of pain following total knee replacement surgery: prosthesis, inflammation and arthrofibrosis.EFORT open reviews · 2020Review
- Postoperative Serum Cytokine Levels Are Associated With Early Stiffness After Total Knee Arthroplasty: A Prospective Cohort Study.The Journal of arthroplasty · 2020Article
- Is EDTA Irrigation Effective in Reducing Bacterial Infection in a Rat Model of Contaminated Intra-articular Knee Implants?Clinical orthopaedics and related research · 2020Article
- Low-grade infections as a possible cause of arthrofibrosis after total knee arthroplasty.Patient safety in surgery · 2019Article
- Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2.The American journal of pathology · 2018Article
- Reply to Editorial by Mamarelis et al.Annals of translational medicine · 2016Article
- [Synovial biomarkers for differential diagnosis of painful arthroplasty].Der Orthopade · 2015Article
- A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.Scientific reports · 2015Article
- Fibrosis is a common outcome following total knee arthroplasty.Scientific reports · 2015Article
- Timing of manipulation under anaesthesia for stiffness after total knee arthroplasty.Annals of translational medicine · 2015Article
- Human xylosyltransferases--mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthrofibrosis is one of the most common complications after total knee arthroplasty with an overall incidence of approximately 10%. Nevertheless, published data are rare and clinical trials mostly include small and heterogeneous patient series resulting in controversial conclusions. Clinically, arthrofibrosis after knee arthroplasty is defined as (painful) stiffness with scarring and soft tissue proliferation. Differentiation between local (peripatellar) and generalized fibrosis is therapeutically relevant. Histopathology typically shows subsynovial fibrosis with synovial hyperplasia, chronic inflammatory infiltration, and excessive and unregulated proliferation of collagen and fibroblasts. Diagnostic strategies are based on the exclusion of differential causes for painful knee stiffness, and especially the exclusion of low-grade infections represents a diagnostic challenge. Early and intensive physiotherapy combined with sufficient analgesia should be initiated as a basic therapy. The next therapeutic steps for persisting arthrofibrosis include closed manipulation and open arthrolysis. Arthroscopic interventions should be limited to local fibrosis. Revision arthroplasty represents a rescue surgery, often associated with recurrence of fibrosis. Prevention of arthrofibrosis by sufficient analgesia and early physiotherapy remains the best treatment option for painful stiffness after knee arthroplasty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.