ArticleThe Journal of investigative dermatology2006
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.
Article in The Journal of investigative dermatology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 93 citations in OpenAlex.
- The Interstitial Collagenases MMP13 and MMP14 Are Dispensable for the Early Onset of Skin Morphogenesis but Modulate Endochondral Ossification.The American journal of pathology · 2026Article
- Article
- Relationship Between Epidermal Matrix Metalloproteinase-1 and Dermal Collagen Reduction in Skin Subjected to Chronic Sun Exposure.Journal of clinical medicine · 2025Article
- Immunomodulation by glucocorticoid-induced leucine zipper in macrophages: enhanced phagocytosis, protection from pyroptosis, and altered mitochondrial function.Frontiers in immunology · 2024Article
- Article
- Wound healing: cellular mechanisms and pathological outcomes.Open biology · 2020Review
- Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review).Biomedical reports · 2020Review
- Limitations of Knockout Mice and Other Tools in Assessment of the Involvement of Matrix Metalloproteinases in Wound Healing and the Means to Overcome Them.ACS pharmacology & translational science · 2020Article
- Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice.Aging · 2020Article
- Review
- Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation.Molecules (Basel, Switzerland) · 2019Review
- Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.Bone research · 2019Article
- Defining stem cell dynamics and migration during wound healing in mouse skin epidermis.Nature communications · 2017Article
- Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals.International journal of cell biology · 2017Review
- MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.The Journal of investigative dermatology · 2015Article
- Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring.Advances in wound care · 2015Review
- Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth.The Journal of biological chemistry · 2014Article
- Article
- ANKRD1 acts as a transcriptional repressor of MMP13 via the AP-1 site.Molecular and cellular biology · 2014Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Degradation of the extracellular matrix, which is an indispensable step in tissue remodelling processes such as embryonic development and wound healing of the skin, has been attributed to collagenolytic activity of members of the matrix metalloproteinase family (MMPs). Here, we employed mmp13 knockout mice to elucidate the function of MMP13 in embryonic skin development, skin homeostasis, and cutaneous wound healing. Overall epidermal architecture and dermal composition of non-injured skin were indistinguishable from wild-type mice. Despite robust expression of MMP13 in the early phase of wound healing, wild-type and mmp13 knockout animals did not differ in their efficiency of re-epithelialization, inflammatory response, granulation tissue formation, angiogenesis, and restoration of basement membrane. Yet, among other MMPs also expressed during wound healing, MMP8 was found to be enhanced in wounds of MMP13-deficient mice. In summary, skin homeostasis and also tissue remodelling processes like embryonic skin development and cutaneous wound healing are independent of MMP13 either owing to MMP13 dispensability or owing to functional substitution by other collagenolytic proteinases such as MMP8.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.