Evidence map›Paper›PMID 1637416›Full record

ArticleJournal of virology1992

Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected].

C J Petropoulos, W Payne, D W Salter, S H Hughes

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  8. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.Proceedings of the National Academy of Sciences of the United States of America · 2000
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  16. Review
  17. Article
  18. Transgenesis in chickens.Transgenic research · 1993
    Review
  19. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C J PetropoulosABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201.
W Payne
D W Salter
S H Hughes
Frederick National Laboratory for Cancer Research · US

Funding

PROVIDE BASIC CANCER RESEARCHN01CO074101 · CO · ADVANCED BIOSCIENCE LABORATORIES, INC. · PI VANDE WOUDE, GEORGE F · 1987 to 1994
–
NCI NIH HHS N01-CO-74101
6 · The paper itself

Abstract

The promoter regions of the chicken skeletal muscle alpha-actin (alpha sk-actin) and the cytoplasmic beta-actin genes were linked to the bacterial chloramphenicol acetyltransferase (CAT) gene. Replication-competent retroviral vectors were used to introduce these two actin/CAT cassettes into the chicken genome. Chickens infected with retroviruses containing the alpha sk-actin promoter expressed high levels of CAT activity in striated muscle (skeletal muscle and heart); much lower levels of CAT activity were produced in the other nonmuscle tissues. In contrast, chickens infected with retroviruses containing the beta-actin promoter linked to the CAT gene expressed low levels of CAT activity in many different tissue types and with no discernible tissue specificity. Data are presented to demonstrate that the high levels of CAT activity that were detected in the skeletal muscle of chickens infected with the retrovirus containing the alpha sk-actin promoter/CAT cassette were not due to preferential infectivity, integration, or replication of the retrovirus vector in the striated muscles of these animals.

Indexed as

ActinsAnimalsBirdsCells, CulturedChick EmbryoChloramphenicol O-AcetyltransferaseDNA, ViralFibroblastsGenetic VectorsOrgan SpecificityPromoter Regions, GeneticProvirusesRecombinant Fusion ProteinsRetroviridaeTransfectionVirus ReplicationActinsChloramphenicol O-AcetyltransferaseDNA, ViralRecombinant Fusion Proteins

Identifiers

PMID1637416
PMCPMC241119
OpenAlexW1736595122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.