ArticleProceedings of the National Academy of Sciences of the United States of America2006
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Clonal, regionally clustered spread-rather than vertical transmission-explains surges in fluoroquinolone‑resistant Campylobacter jejuni in Finnish broilers.Acta veterinaria Scandinavica · 2026Article
- l-Fucose is a candidate monosaccharide neuromodulator and mitigates Alzheimer's synaptic deficits.Science advances · 2025Article
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- Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.Journal of neurochemistry · 2023Article
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- FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.Molecular medicine (Cambridge, Mass.) · 2023Article
- Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates.Advances in neurobiology · 2023Article
- Targeting cell surface glycans with lectin-coated fluorescent nanodiamonds.Nanoscale advances · 2022Article
- Bisecting Lewis X in Hybrid-TypeAnalytical chemistry · 2021Article
- The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease.Journal of neurochemistry · 2021Article
- Review
- Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease.International journal of molecular sciences · 2021Article
- Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development.Molecules (Basel, Switzerland) · 2020Article
- Two New Fucose-α (1-2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven.Scientific reports · 2019Article
- Post-traumatic stress disorder affects fucose-α(1-2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy.Translational psychiatry · 2019Article
- Review
- Biological functions of fucose in mammals.Glycobiology · 2017Review
- Glycan Engineering for Cell and Developmental Biology.Cell chemical biology · 2016Review
- Article
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Authors and funding
7 authors.
Funding
Abstract
Although fucose-alpha(1-2)-galactose [Fucalpha(1-2)Gal] carbohydrates have been implicated in cognitive processes such as long-term memory, the molecular mechanisms by which these sugars influence neuronal communication are not well understood. Here, we present molecular insights into the functions of Fucalpha(1-2)Gal sugars, demonstrating that they play a role in the regulation of synaptic proteins and neuronal morphology. We show that synapsins Ia and Ib, synapse-specific proteins involved in neurotransmitter release and synaptogenesis, are the major Fucalpha(1-2)Gal glycoproteins in mature cultured neurons and the adult rat hippocampus. Fucosylation has profound effects on the expression and turnover of synapsin in cells and protects synapsin from degradation by the calcium-activated protease calpain. Our studies suggest that defucosylation of synapsin has critical consequences for neuronal growth and morphology, leading to stunted neurite outgrowth and delayed synapse formation. We also demonstrate that Fucalpha(1-2)Gal carbohydrates are not limited to synapsin but are found on additional glycoproteins involved in modulating neuronal architecture. Together, our studies identify important roles for Fucalpha(1-2)Gal sugars in the regulation of neuronal proteins and morphological changes that may underlie synaptic plasticity.
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