ArticleProceedings of the National Academy of Sciences of the United States of America2006
Silent plateau potentials, rhythmic bursts, and pacemaker firing: three patterns of activity that coexist in quadristable subthalamic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Artificial plateau neurons with in-situ spike-malleability for rhythmic quadrupedal locomotion.Nature communications · 2026Article
- Interleaved single and bursting spiking resonance in neurons.PLoS computational biology · 2025Article
- An unusual potassium conductance protectsProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Magnetic Flux Sensor Based on Spiking Neurons with Josephson Junctions.Sensors (Basel, Switzerland) · 2024Article
- Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease.Scientific reports · 2022Article
- TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect GProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models.Experimental neurology · 2022Review
- Modeling Working Memory in a Spiking Neuron Network Accompanied by Astrocytes.Frontiers in cellular neuroscience · 2021Article
- Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits.The Journal of clinical investigation · 2018Article
- Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory.Annual review of neuroscience · 2017Review
- Slow Bursting Neurons of Mouse Cortical Layer 6b Are Depolarized by Hypocretin/Orexin and Major Transmitters of Arousal.Frontiers in neurology · 2016Article
- AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons.Neuroscience · 2014Article
- Predicting the responses of repetitively firing neurons to current noise.PLoS computational biology · 2014Article
- Group I mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neurons.The Journal of pharmacology and experimental therapeutics · 2013Article
- Signal enhancement in the output stage of the basal ganglia by synaptic short-term plasticity in the direct, indirect, and hyperdirect pathways.Frontiers in computational neuroscience · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease.Neuroscience · 2011Article
- The Subthalamic Nucleus becomes a Generator of Bursts in the Dopamine-Depleted State. Its High Frequency Stimulation Dramatically Weakens Transmission to the Globus Pallidus.Frontiers in systems neuroscience · 2011Article
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2 authors.
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Abstract
Subthalamic neurons display uncommon intrinsic behaviors that are likely to contribute to the motor and cognitive functions of the basal ganglia and to many of its disorders. Here, we report silent plateau potentials in these cells. These plateau responses start with a transient burst of action potentials that quickly diminish in amplitude because of spike inactivation and current shunt. The resulting interruption of spiking reveals a stable depolarization (up state) that clamps the cell membrane potential near -40 mV for several seconds. These plateau potentials coexist in single subthalamic neurons with more familiar patterns of burst and pacemaker firing. Within a narrow range of baseline membrane potentials (-67 to -60 mV), depolarization abruptly switches single cells from bistable to rhythmic bursts or tonic firing modes, thus selecting entirely distinct algorithms for integrating cortical and pallidal synaptic inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.