Evidence map›Paper›PMID 16373488›Full record

ArticleRNA (New York, N.Y.)2006

40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element.

Kevin Czaplinski, Iain W Mattaj

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  12. Early zebrafish development: it's in the maternal genes.Current opinion in genetics & development · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin CzaplinskiEMBL Gene Expression Programme, Heidelberg, Germany. czaplins@aecom.yu.edu
Iain W Mattaj
European Molecular Biology Organization · DE

Funding

ELUCIDATING THE MECHANISM OF U SNRNA EXPORTF32GM020034 · NIGMS · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI CZAPLINSKI, KEVIN · 1999 to 2001
$73k
NIGMS NIH HHS F32 GM020034
6 · The paper itself

Abstract

Localizing mRNAs within the cytoplasm gives cells the ability to spatially restrict protein production, a powerful means to regulate gene expression. Localized mRNA is often visible in microscopically observable particles or granules, and the association of mRNA localization with these structures is an indication that particles or granules may be essential to the localization process. Understanding how such structures form will therefore be important for understanding the function of localization RNPs (L-RNPs). We previously identified a novel component of an L-RNP from the Vg1 mRNA from Xenopus oocytes called 40LoVe. 40LoVe interaction with the Vg1-localization element (Vg1LE) was previously shown to be dependent on the VM1 and E2 sequence motifs within the Vg1LE that cross-link to hnRNP I and Vg1RBP/Vera, respectively. We report interaction of these motif-binding proteins with 40LoVe and identify a 40LoVe-Xenopus hnRNP D/AUF1 interaction. We further demonstrate that titration of VM1 and E2 motif binding activity in vivo surprisingly suggests that the motif binding proteins have differing roles during Vg1LE-dependent mRNA localization.

Indexed as

Protein Sorting SignalsAnimalsBinding SitesCytoplasmEstradiolFemaleGlycoproteinsHeterogeneous-Nuclear Ribonucleoprotein DHeterogeneous-Nuclear RibonucleoproteinsOocytesOogenesisPeptidesRNA-Binding ProteinsTransforming Growth Factor betaXenopus laevisXenopus ProteinsEstradiolGDF1 protein, XenopusGlycoproteinsHeterogeneous-Nuclear Ribonucleoprotein DHeterogeneous-Nuclear RibonucleoproteinsIGF2BP3 protein, XenopusPeptidesProtein Sorting SignalsRNA-Binding ProteinsTransforming Growth Factor betaXenopus Proteins

Identifiers

PMID16373488
PMCPMC1370901
OpenAlexW2097477219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.