ArticleInternational journal of epidemiology2006
Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort.
Article in International journal of epidemiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial.Journal of general internal medicine · 2007Trial
- Metabolic syndrome and cardiovascular disease among adult cancer patients: results from NHANES 2007-2018.BMC public health · 2024Article
- Four-years change of BMI and waist circumference are associated with metabolic syndrome in middle-aged and elderly Chinese.Scientific reports · 2024Article
- Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study.Journal of atherosclerosis and thrombosis · 2022Observational
- Association between weight change and risk of metabolic abnormalities in non-overweight/obese and overweight/obese population: A retrospective cohort study among Chinese adults.Frontiers in endocrinology · 2022Article
- Patterns of Weight Change One Year after Delivery Are Associated with Cardiometabolic Risk Factors at Six Years Postpartum in Mexican Women.Nutrients · 2020Article
- The Impact of BMI Categories on Metabolic Abnormality Development in Chinese Adults Who are Metabolically Healthy: A 7-Year Prospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Baseline levels, and changes over time in body mass index and fasting insulin, and their relationship to change in metabolic trait clustering.Metabolic syndrome and related disorders · 2014Article
- Fish consumption is inversely associated with the metabolic syndrome.European journal of clinical nutrition · 2014Article
- Article
- Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.The Journal of pediatrics · 2012Article
- Effect of longitudinal changes in visceral fat area and other anthropometric indices to the changes in metabolic risk factors in Japanese men: the Hitachi Health Study.Diabetes care · 2012Article
- Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia.Journal of the American College of Cardiology · 2012Article
- Metabolic syndrome in the Middle East.Indian journal of endocrinology and metabolism · 2012Article
- Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women.Diabetologia · 2011Article
- Metabolic syndrome: definitions and controversies.BMC medicine · 2011Review
- Excessive 5-year weight gain predicts metabolic syndrome development in healthy middle-aged adults.World journal of diabetes · 2011Article
- Differential association of anthropometric parameters with coronary risk in women--data of the CORA study.Obesity facts · 2011Article
- Weight change over five-year periods and number of components of the metabolic syndrome in a Dutch cohort.European journal of epidemiology · 2010Article
- Weight change and incident metabolic syndrome in Iranian men and women; a 3 year follow-up study.BMC public health · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHow weight change affects the metabolic syndrome (MS) and its parameters is unknown, particularly, in a leaner European population such as the French prospective D.E.S.I.R. cohort.
methodsIn 3770 D.E.S.I.R. participants (sex ratio=1) averaging 47.5 years (range 30-64), with measured weight and MS parameters at baseline (D0) and at 6 year follow-up (D6), we assessed this relationship across five weight-change classes, using stable weight as the referent group (-2 to +2 kg). We used analysis-of-covariance to assess changes in each MS parameter and logistic regression to assess incident MS, according to the National Cholesterol Education Program (NCEP). We also assessed weight-change effect on MS status between D0 and D6.
resultsAt D0, average weight was 68.4 kg (SD 12.3); BMI was 24.8 kg/m2 (SD 3.5). From D0-D6, the cohort gained a mean 2.1 kg (median 2.0; SD 4.4). After adjustment for age and D0 weight, there was a strong linear relationship with weight change and worsening of the following MS parameters at D6: fasting insulin, waist girth, fasting glucose, fasting triglycerides, HDL cholesterol, and systolic and diastolic blood pressure (P<0.0001). After age adjustment, for every kilogram gained over 6 years, risk of developing the NCEP Syndrome increased 22% (OR 1.22; 95% CI 1.18-1.25). NCEP-MS was incident in 3% of those with stable weight compared with 21% among those gaining >9 kg; 10% of those who lost >2 kg reverted to non-NCEP-MS.
conclusionsAll continuous MS measures are linearly related to weight change, and MS can resolve with modest weight loss, underscoring the importance of maintaining lifelong normal weight.
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